Neuroprotective Effect of WEB 1881 FU (Nebracetam) on an Ischemia-Induced Deficit of Glucose Uptake in Rat Hippocampal and Cerebral Cortical Slices and CA1 Field Potential in Hippocampal Slices.
スポンサーリンク
概要
- 論文の詳細を見る
Effect of WEB 1881 FU (nebracetam) on hypoxia and ischemia-induced impairment of 2-deoxyglucose (2DG) uptake and CA1 field potentials induced by hypoxia and hypoxia/hypoglycemia (ischemia) in rat brain slices was evaluated and compared to the findings obtained with pentobarbital and idebenone. Hippocampal and cortical slices were exposed to 15-20 min of ischemia, and then these slices were returned to oxygenated and glucose-containing buffer for 6 hr. Ischemia reduced both 30 mM KCl-induced 2DG uptake and CA1 field potentials elicited by the stimulation of Schaffer collaterals in the hippocampus. Pretreatment of nebracetam at 1 mM or pentobarbital at 0.1 mM attenuated a decline of 2DG uptake and CA1 field potentials under the condition of ischemia. In addition, nebracetam and pentobarbital relatively recovered the increase of 2DG uptake in the hippocampus under hypoxia for 45 min. Furthermore, these drugs also attenuated the decline of 2DG uptake induced by 10 mM glutamate for 20 min. However, treatment with idebenone did not recover the deficit of 2DG uptake and CA1 field potential. The present result suggests that nebracetam and pentobarbital exert neuroprotective actions against not only ischemia but also glutamate toxicity.
- 公益社団法人 日本薬理学会の論文
著者
-
Watanabe Shigenori
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
-
Shibata Shigenobu
Department Of Pharmacology Faculty Of Human Sciences Waseda University
-
Kagami-ishi Yoshifumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
-
UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
関連論文
- Entrainment Function in the Suprachiasmatic Nucleus of Streptozotocin-Induced Diabetic Rats
- Time-Dependent Effect of Glutamate on Long-Term Potentiation in the Suprachiasmatic Nucleus of Rats
- Both Metabotropic Glutamate I and II Receptors Mediate Augmentation of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
- Effects of Adenosine A_1- and A_-Receptor Agonists on Enhancement of Dopamine Release From the Striatum in Methamphetamine-Sensitized Rats
- Repeated Adenosine Pre-treatment Potentiates the Acute Effect of Methamphetamine in Rats
- Vulnerability of Synaptic Plasticity in the Striatum of Methamphetamine-Sensitized Rats
- Methamphetamine : Induced Sensitization of Dopamine Release via a Metabotropic Glutamate Receptor Mediated Pathway in Rat Striatal Slices
- Different Effects of Trypsin Inhibitors on Intestinal Gene Expression of Secretin and on Pancreatic Bicarbonate Secretion in CCK-A-Receptor-Deficient Rats
- Lowered Entrainment Function in the Suprachiasmatic Nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) Rats
- Involvement of the Medial Amygdaloid Nucleus in the Action of Imipramine in Rats Subjected to the Forced Swimming Test
- A NEW FORCED SWIMMING TEST FOR THE EVALUATION OF ANTIDEPRESSANTS IN RATS BY RECORDING VIBRATION OF A WATER TANK
- Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices
- PE-373 The functional role of the central and peripheral clock for regulating blood pressure.(Hypertension, Basic 4 (H) : PE64)(Poster Session (English))
- PHARMACOLOGICAL CHARACTERISTICS OF ABNORMAL BEHAVIOR INDUCED BY HARMINE WITH SPECIAL REFERENCE TO TREMOR IN MICE
- Circadian Rhythms in the CNS and Peripheral Clock Disorders : The Circadian Clock and Hyperlipidemia
- Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice
- A Key Role of the Mammillary Body in Mediation of the Antianxiety Action of Zopiclone, a Cyclopyrrolone Derivative
- THE EFFECT OF AGE ON THE DEVELOPMENT OF HYPEREMOTIONALITY FOLLOWING BILATERAL OLFACTORY BULBECTOMY IN RATS
- THE ROLE OF NORADRENERGIC AND SEROTONERGIC SYSTEMS IN THE HIPPOCAMPAL KINDLING EFFECT
- EFFECTS OF RESERPINE, α-METHYL-p-TYROSINE, P-CHLOROPHENYLALANINE AND 5, 7-DIHYDROXYTRYPTAMINE ON THE HIPPOCAMPAL KINDLING EFFECT IN RATS
- EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL ON THE CARDIOVASCULAR SYSTEM, AND PRESSOR AND BEHAVIORAL RESPONSES TO BRAIN STIMULATION IN RATS
- Inhibitory Action of 5-HT_ Agonist MKC-242 on Triazolam-Induced Phase Advances in Hamster Circadian Activity Rhythms
- EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2, 5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
- EFFECTS OF LOCUS COERULEUS STIMULATION ON MURICIDE IN OLFACTORY BULBECTOMIZED AND RAPHE LESIONED RATS
- EFFECT OF AMINO ACIDS AND MONOAMINES ON THE NEURONAL ACTIVITY OF SUPRACHIASMATIC NUCLEUS IN HYPOTHALAMIC SLICE PREPARATIONS
- EFFECTS OF PSYCHOTROPIC DRUGS INJECTED INTO THE LIMBIC STRUCTURES ON MOUSE-KILLING BEHAVIOR IN THE RAT WITH OLFACTORY BULB ABLATIONS
- EFFECTS OF ELECTROCONVULSIVE SHOCK ON MOUSE-KILLING BEHAVIOR (MURICIDE) IN OLFACTORY BULBECTOMIZED RATS
- Circadian Rhythms in the CNS and Peripheral Clock Disorders : Preface
- EFFECT OF DESIPRAMINE ON NORADRENERGIC INHIBITION OF AMYGDALOID EVOKED POTENTIAL
- Circadian Clock Gene Expression and Brain Function
- EFFECT OF STIMULATION OF LOCUS COERULEUS ON THE EVOKED POTENTIAL IN THE AMYGDALA IN RATS
- POSSIBLE INVOLVEMENT OF A CENTRAL NORADRENERGIC SYSTEM IN AUTOMUTILATION INDUCED BY CLONIDINE IN MICE
- CHANGES IN SENSITIVITY OF MICE TO ANTICONVULSANT DRUGS FOLLOWING BILATERAL OLFACTORY BULB ABLATIONS
- EFFECTS OF MONOAMINES INJECTED INTO THE HIPPOCAMPUS ON HIPPOCAMPAL SEIZURE DISCHARGES IN THE RABBIT
- EFFECT OF MEDIAN RAPHE STIMULATION ON HIPPOCAMPAL SEIZURE DISCHARGE INDUCED BY CARBACHOL IN THE RABBIT
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPEREMOTION-ALITY OF RATS WITH BILATERAL ABLATIONS OF THE OLFACTORY BULBS AND OLFACTORY TUBERCLES
- HYPEREMOTIONALITY INDUCED BY LESIONS IN THE OLFACTORY SYSTEM OF THE RAT
- Behavioral analysis of zopiclone on the basis of their discriminative stimulus properties in the rat.
- Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neuronal damage using rat striatal slices.
- Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative.
- Inhibitory Effect of NMDA on Dopaminergic Transmission in a Slice Preparation of Rat Globus Pallidus.
- .BETA.-CCM inhibits muricide induced by olfactory bulbectomy in rats.
- WEB 1881 FU ameliorates impairement of working memory induced by scopolamine and cerebral ischemia in the three-panel runway task.
- Role of the amygdala in the hippocampal kindling effect of rats.
- Neuroprotective Effect of WEB 1881 FU (Nebracetam) on an Ischemia-Induced Deficit of Glucose Uptake in Rat Hippocampal and Cerebral Cortical Slices and CA1 Field Potential in Hippocampal Slices.
- Nootropic Candidates Inhibit Head-Twitches Induced by Mescaline in Mice.
- Nebracetam (WEB 1881FU) Prevents N-Methyl-D-Aspartate Receptor-Mediated Neurotoxicity in Rat Striatal Slices.
- Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative.
- The effect of agonists at the GABA-benzodiazepine-receptor-complex on the proconflict effect induced by .BETA.-CCM and pentetrazol in rats.
- Effects of adrenergic blockers on the inhibition of muricide by chronic administration of desipramine in oflactory bulbectomized rats.
- The effect of a selective phosphodiesterase inhibitor, rolipram, on muricide in olfactory bulbectomized rats.
- Protective Effect of Minaprine against the Abnormal Changes of 2-Deoxyglucose Uptake by Rat Hippocampal Slices Induced by Hypoxia/Hypoglycemia.