SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
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概要
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The significance of the naloxone-induced jumping response in predicting the physical dependence capacity of morphine-like analgesics was investigated in mice treated with morphine, morphine-6-glucuronide and pentazocine. The jumping response was induced by naloxone in mice chronically treated with morphine and morphine-6-glucuronide, but its development is not necessarily related to the number or frequency of drug injections, and it was also observed even after a single dose of the drugs. The jumping was not precipitated in mice chronically treated with pentazocine. The naloxone-induced jumping response in mice treated with morphine was not masked by morphine, but was markedly suppressed by chlordiazepoxide, diazepam, methamphetamine, delta-9-tetrahydrocannabinol and diphenylhydantoin. It is concluded that the naloxone-induced jumping response is not a specific abstinence phenomenon in mice treated with morphine-like analgesics, although it may be used for a first screening test to estimate a physical dependence capacity.
- 社団法人 日本薬理学会の論文
著者
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Ueki Showa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyushu University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Shimomura Kyoichi
Department Of Pharmacology Pharmacological Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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KAMEI Chiaki
Department of Pharmacology, Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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UEKI Showa
Department of Phamacology, Faculty of Pharmaceutical Sciences, Kyushu University
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