Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
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概要
- 論文の詳細を見る
Effect of docosahexaenoic acid (DHA) [22:6(n-3)]-fortified Chlorella oil fraction on radial maze performance was studied in aged mice. Male ICR mice aged 9 months were fed a diet containing 2g DHA-fortified Chlorella oil fraction/100g diet or normal diet (Control group) for 2 months. Two months after the start of feeding, the mice were tested for learning ability related to 2 types of memory, reference memory and working memory, with the partially (4 of 8) baited eight-arm radial maze. Reference memory is a kind of information that should be retained until the next trial. Working memory is a kind of information that disappears in a short time. Entry into the unbaited arms and repeated entry into the visited arms were defined as reference memory errors and working memory errors, respectively. DHA-fortified Chlorella oil fraction administration to mice for 2 months resulted in a significant decrease in the number of working memory errors without affecting the number of reference memory errors. A significant increase in the DHA content in the brain was also observed. These results suggest that the intake of DHA-fortified Chiorella oil fraction effectively enhances working memory in maze performance.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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杉本 由美
神戸薬科大学、薬理学研究室
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KONISHI Fumiko
Chlorella Industry Co. Ltd.
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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SUGIMOTO Yukio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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Sugimoto Yumi
Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O
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Tanaka K
Chlorella Industry Co. Ltd.
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Sugimoto Yumi
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Women's College Of Pharmacy.
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Sugimoto Yukio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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TAGA Chiyomi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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NISHIGA Miyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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FUJIWARA Madoka
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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TANAKA Kuniaki
Chlorella Industry Co., Ltd.
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Taga Chiyomi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Nishiga Miyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Fujiwara M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Fujiwara Madoka
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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