The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
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概要
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The present study was undertaken to clarify the effects of selective serotonin-reuptake inhibitors (SSRIs) on visual evoked potential (VEP) in rats. To elucidate the mechanism of action of SSRIs, some serotonin (5-HT) agonists were used. SSRIs, fluvoxamine and paroxetine, caused a reduction in the amplitudes of P1-N1, P3-N3, and N3-P4 components of VEP. The amplitude of the P1-N1 component was also reduced by the 5-HT1A agonist 8-OH-DPAT and 5-HT1B agonist anpirtoline. On the other hand, amplitudes of P3-N3 and N3-P4 components were reduced by anpirtoline and the 5-HT2 agonist DOI. These results indicate that the reduction in the amplitude of the P1-N1 component of VEP induced by SSRIs may participate in 5-HT1A and 5-HT1B receptors, and those of P3-N3 and N3-P4 components induced by SSRIs may be closely related with 5-HT1B and 5-HT2 receptors.
- 社団法人 日本薬理学会の論文
- 2004-03-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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FUJII Yoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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IWAMURA Yoshihiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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Fujii Yoko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Fujii Yoko
Department Of Agriculture And Horticulture Kobe University
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Iwamura Yoshihiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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