Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice(Biopharmacy)
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概要
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We investigated the effect of Lactobacillus acidophilus strain L-55 isolated from infant feces on experimental allergic rhinitis in BALB/c mice. The heat-treated cells of strain L-55 were orally administrated for 4 consecutive weeks to mice sensitized by ovalbumin (OVA), and nasal symptoms (sneezing and nasal rubbing) induced by OVA challenge were evaluated. Strain L-55 at doses of 1 and 10mg cells/mouse significantly inhibited nasal symptoms by repeated administration over a period of 2 weeks. Furthermore, we measured the level of OVA-specific IgE titers in the serum by passive cutaneous anaphylaxis (PCA) reaction. PCA titers in the sera from mice administrated strain L-55 were significantly lowered compared with the control. These results suggest that oral administration of strain L-55 may be useful for alleviating the nasal symptoms of allergic rhinitis.
- 公益社団法人日本薬学会の論文
- 2007-11-01
著者
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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SUNADA Yosuke
Fundamental Laboratory, Ohayo Dairy Products Co., Ltd.
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NAKAMURA Syoji
Fundamental Laboratory, Ohayo Dairy Products Co., Ltd.
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Nakamura Syoji
Fundamental Laboratory Ohayo Dairy Products Co. Ltd.
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Sunada Yosuke
Fundamental Laboratory Ohayo Dairy Products Co. Ltd.
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