Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
スポンサーリンク
概要
- 論文の詳細を見る
Six flavonoid glycosides, eriocitrin(1), narirutin(2), hesperidin(3), luteolin-7-O-rutinoside(4), isorhoifolin(5), diosmin(6), rosmarinic acid(7)and 5, 7-dihydroxtcromone-7-O-rutioside(8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses or 100 and 300mg/kg. These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.
- 社団法人日本薬学会の論文
- 2002-02-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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益田 秀樹
神奈川科学技術アカデミー
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杉本 由美
神戸薬科大学、薬理学研究室
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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Masuda Hideki
Ogawa & Co. Ltd. Material R&d Laboratory
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INOUE Toshio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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SUGIMOTO Yukio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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Sugimoto Yumi
Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O
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Masuda Hideki
Ogawa & Co. Ltd.
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Inoue T
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University:ogawa & Co. Ltd
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Sugimoto Yumi
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Women's College Of Pharmacy.
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Inoue Toshio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Sugimoto Yukio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Inoue Toshio
Dep. Of Pharmacotherapy Nihon Pharmaceutical Univ.
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Inoue Toshio
Department Of Cardiology Yufuin Kohseinenkin Hospital
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Inoue Toshio
Material R&d Laboratory Ogawa & Co. Ltd.
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