Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in Mice
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概要
- 論文の詳細を見る
The changes of electroencephalogram induced by maximal electroshock were studied in comparison with behavioral seizures in mice. After electroshock, mice showed tonic flexor (TF) seizure, tonic extensor (TE) seizure, and clonic (CL) seizure, in this order of occurrence. At the same time, high frequency spike or spike and wave complex in the cortex was observed, and thereafter, the frequency of the spike or spike and wave complex gradually fell. The antiepileptics used in the present study, except for ethosuximide, caused a dose-dependent shortening of the TE seizure duration. In addition, phenobarbital and carbamazepine at relatively high doses also showed a significant shortening of the duration of CL seizure. Although the duration of total electroencephalographic (EEG) seizures was not influenced by all the antiepileptics used in the present study, the duration of high frequency spike or spike and wave complex observed for 7 – 8 s after electroshock was dose-dependently shortened by all the antiepileptics used. From these findings, it may be concluded that high frequency spike or spike and wave complex induced by maximal electroshock is a useful index to assess antiepileptics that are effective in not only tonic-clonic seizures but also absence seizures in humans.
- 社団法人 日本薬理学会の論文
- 2008-01-20
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Watanabe Yusuke
Department of Materials Engineering, The University of Tokyo
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Watanabe Yusuke
Department Of Cardiology Sakakibara Heart Institute
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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TAKECHI Kenshi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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MURAKAMI Aya
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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FUJIWARA Akinori
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Watanabe Yusuke
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Murakami Aya
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Takechi Kenshi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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FUJIWARA Akinori
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Takechi Kenshi
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Takechi Kenshi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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