Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats(Pharmacology)
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概要
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The present study was undertaken to clarify the epileptogenic activity induced by intracerebroventricular injection (i.c.v.) of antibiotics effective in methicillin-resistant Staphylococcus aureus (MRSA) in chronically electrode implanted rats. Teicoplanin (10-100μg, i.c.v.) caused dose-related electroencephalographic (EEG) seizure characterized by an uninterrupted high voltage and wave complex. At the same time, the rats showed forelimb clonus, head nodding, jumping and severe convulsion. At a high dose (100μg, i.c.v.), the drug caused a severe twisting immediately after the intracerebroventricular injection (i.c.v.) followed by jumping and violent convulsion with a continuous rhythmic spike and wave complex in EEG. On the other hand, vancomycin (30-1000μg, i.c.v.) caused no or almost no epileptogenic activity in terms of behavior and in EEG. However, at a high dose (1000μg, i.c.v.), the drug caused an occasional spike from the hippocampus without showing any behavioral changes in the rats. Fosfomycin (30-1000μg, i.c.v.), cefazolin (10-100μg, i.c.v.) and penicillin G (30-300μg, i.c.v.), used as reference drugs, caused dose-dependent epileptogenic activity in both EEG. From these findings, it was found that teicoplanin caused a potent epileptogenic activity, different to vancomycin. Therefore, it can be concluded that vancomycin may be safety on epileptogenic activity used for the clinical purpose of infections caused by MRSA.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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ISHIKAWA TAKASHI
Department of Gastroenterology, Faculty of Medicine, The University of Tokyo
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Rahman Md.
Department Of Agriculture Bsmrau
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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AGO Jun
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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MATSUMOTO Naotaka
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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RAHMAN Ashequr
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Ishikawa Takashi
Department Of Gastroenterological Surgery Yokohama City University Postgraduate School Of Medicine
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Ago Jun
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Matsumoto Naotaka
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishikawa Takashi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishikawa Takashi
Department Of Breast And Thyroid Surgery Yokohama City University Medical Center
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ISHIKAWA Takashi
Department of Applied Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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