Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance
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概要
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We investigated the participation of γ-aminobutyric acid (GABA) neurons of the medial septal area in eight-arm radial maze performance in rats. The intra-septal injection of muscimol, a GABAA agonist, caused an increase in total error and working memory error. On the other hand, no significant effect was observed with reference memory error. Donepezil and tacrine (cholinesterase inhibitors) antagonized the muscimol-induced spatial memory deficits. Histidine (1500 mg/kg, i.p.) also improved the total error and working memory error induced by muscimol. At this dose, histidine caused a significant increase in the histamine content of the cortex, hippocampus, and hypothalamus in rats. In addition, the intra-hippocampal injection of histamine also antagonized muscimol-induced spatial memory deficits. The practical conclusion is that the GABAA receptor of the medial septal area plays an important role in working memory, and also, the disturbance of working memory induced by muscimol is mediated not only by cholinergic but also by histaminergic systems in the spatial memory of rats.
- 社団法人 日本薬理学会の論文
- 2007-07-20
著者
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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Yamamoto Yasuko
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Mikami Azusa
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Mikami Azusa
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Fujii Yoko
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Fujii Yoko
Department Of Agriculture And Horticulture Kobe University
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