Effect of Methylcarbonylmethyl 2(S)-[4-(4-Guanidino-benzoyloxy)phenyl] Propionate Methanesulfonate (TT-S24) on Experimental Pancreatitis in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effect of methylcarbonylmethyl 2(S)-[4-(4-guanidino-benzoyloxy) phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats was examined in comparison with that of camostat. TT-S24 showed a preventive effect on increases in plasma amylase activity and pancreatic weight induced by cerulein injection. TT-S24 also reduced an increase in plasma amylase activity induced by taurocholate. TT-S24 effectively prevented the mortality induced by an injection of a mixture of trypsin and taurocholate. TT-S24 showed no effect on an increase in amylase activity 6 h after duodenum ligation (closed duodenal loop pancreatitis), indicating that the drug had no effect on the initiation and propagation step of closed duodenal loop pancreatitis. On the other hand, TT-S24 reduced an increase in amylase activity 6 h after release of the duodenum ligation. TT-S24 showed anti-trypsin, anti-kallikrein, anti-thrombin and anti-plasmin activities. The effect of TT-S24 on some experimental pancreatitis models was nearly equal to or somewhat more potent in most instances to that of camostat. Therefore, TT-S24 should be useful in the clinical treatment of pancreatitis.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
-
Yoshida Y
Yakult Central Inst. For Microbiological Res.
-
Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
-
Tagami H
Teikoku Chemical Industries Co. Ltd. :department Of Pharmacology Faculty Of Pharmaceutical Sciences
-
TAGAMI Hiroyuki
Teikoku Chemical Industries Co., Ltd.,
-
ABE Shin-ichi
Teikoku Chemical Industries Co., Ltd.,
-
YOSHIDA Yasuko
Teikoku Chemical Industries Co., Ltd.,
-
TANAKA Ikuo
Teikoku Chemical Industries Co., Ltd.,
-
Abe Shin-ichi
Teikoku Chemical Industries Co. Ltd.
-
Yoshida Yasuko
Teikoku Chemical Industries Co. Ltd.
-
Tanaka Ikuo
Teikoku Chemical Industries Co. Ltd.
関連論文
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate–Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats
- Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- Interaction between Hippocampal γ-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats
- Anticonvulsant Effect of (RS)-1-Aminoindan-1,5-dicarboxylic Acid on Pentetrazol-Induced Kindled Seizures in Mice
- Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
- Effects of Peppermint (Mentha piperita L.) Extracts on Experimental Allergic Rhinitis in Rats
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- Participation of GABAergic and Histaminergic Systems in Inhibiting Amygdaloid Kindled Seizures
- Slow Wave Sleep-inducing Effects of First Generation H_1-Antagonists
- Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia
- Preparation and Characterization of Two Crystalline Forms of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159)
- Synthesis and Pharmacological Activity of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159) and Its Optical Isomers
- Development of Amygdaloid Kindling in Histidine Decarboxylase-deficient and Histamine H_1 Receptor-deficient Mice
- Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust(Pharmacology)
- Effects of the Cell Wall of Kluyveromyces marxianus YIT 8292 on the Plasma Cholesterol and Fecal Sterol Excretion in Rats Fed on a High-Cholesterol Diet
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice
- Dioxopyrrolines.LXII. Diels-Alder Reaction of 1-Aryl-4-and 5-methoxycarbonyl-1H-pyrrole-2,3-diones with Various 1,3-Dienes
- Synthesis of Glycosylcurcuminoids
- Studies on Panax Acetylenes : Absolute Structure of a New Panax Acetylene, and Inhibitory Effects of Related Acetylenes on the Growth of L-1210 Cells
- Synthesis of Panax Acetylenes : Chiral Syntheses of Acetylpanaxydol, PQ-3 and Panaxydiol
- Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
- Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate-Receptor Blockade
- Influences of Histamine H_1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats(Pharmacology)
- Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats(Pharmacology)
- Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice
- Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns
- Participation of Histamine H_3 Receptors in Experimental Allergic Rhinitis of Mice
- The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
- Comparative Study of Certain Antibiotics on Epileptogenic Property, Including (1Rpi, 5S, 6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)] thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (LJC10627), a Carbapenem Antibiotic wit
- Purification and Characterization of Sulochrin Oxidase from Penicillium frequentans
- PD48 SULOCHRIN OXIDASE FROM PENICILLIUM FREQUENTANS
- Mechanism of the Inhibitory Effect of Histamine on Amygdaloid-Kindled Seizures in Rats
- Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
- Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
- Role of Substance P on Histamine H_3 Antagonist-Induced Scratching Behavior in Mice
- Caffeic Acid Inhibits Compound 48/80-Induced Allergic Symptoms in Mice(Pharmacology)
- Potent Hypocholesterolemic Activity of the Yeast Kluyveromyces marxianus YIT 8292 in Rats Fed a High Cholesterol Diet
- Inhibitory Effects of N-(3,5-Dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine (YIC-C8-434), an Acyl-CoA:Cholesterol O-Acyltransferase Inhibitor, on Cholesterol Esterification in the Intestine and Liver(Pharmacology)
- The Metabolic Stability of Acyl-CoA: Cholesterol O-Acyltransferase (ACAT) Inhibitors, N-(4-Benzyloxy-3,5-dimethoxycinnamoyl)-N'-(2,4- dimethylphenyl)piperazine (YIC-708-424) and Its Derivatives in Rat Liver and Intestinal Epithelium
- Structure-Activity Relationships of N-(3, 5-Dimethoxy-4-n-octyloxycinnamoyl)-N'-(3, 4-dimethylphenyl)piperazine and Analogues as Inhibitors of Acyl-CoA : Cholesterol O-Acyltransferase
- Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
- Influences of Everninomicin, Vancomycin and Teicoplanin on Chemical Mediator Release From Rat Peritoneal Mast Cells
- Increasing Effect by Simultaneous Use of Levocabastine and Pemirolast on Experimental Allergic Conjunctivitis in Rats(Pharmacology)
- DIFFERENTIAL ANTAGONISM OF ANTIAVOIDANCE, CATALEPTIC AND PTOTIC EFFECTS OF NEUROLEPTICS BY BIPERIDEN
- EFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE
- Preventive Effect of Streptococcus thermophilus YIT 2001 on Dextran Sulfate Sodium-Induced Colitis in Mice
- Effect of Probiotics, Bifidobacterium breve and Lactobacillus casei, on Bisphenol A Exposure in Rats
- Effect of Kluyveromyces marxianus YIT 8292 Crude Cell Wall Fraction on Serum Lipids in Normocholesterolemic and Mildly Hypercholesterolemic Subjects
- Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
- Effects of Histidine on Working Memory Deficits Induced by the 5-HT_-Receptor Agonist 8-OH-DPAT
- Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats
- Mechanism of Bradykinin-Induced Histamine Release from Rat Peritoneal Mast Cells
- Effects of Anti-dementia Drugs on Morphine-Induced Somnolence
- Effects of Hop Extracts on Nasal Rubbing and Sneezing in BALB/c Mice(Pharmacology)
- Effects of Antiepileptics on Lateral Geniculate Nucleus-Kindled Seizures in Rats
- Effects of a Dictamnus dasycarpus T. Extract on Allergic Models in Mice
- Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in Mice
- Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions(Pharmacology)
- Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice(Pharmacology)
- Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice
- Characteristics of Scratching Behavior Induced by Some Chemical Mediators in Hairless Mice
- Antipruritic and Antierythema Effects of Ascomycete Bulgaria inquinans Extract in ICR Mice(Pharmacology)
- Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on Nasal Rubbing and Scratching Behavior in ICR Mice(Pharmacology)
- Effects of Cholinergic Drugs and Cerebral Metabolic Activators on Memory Impairment in Old Rats
- EPILEPTOGENIC ACTIVITY INDUCED BY INTRAVENOUS INJECTION OF CERTAIN CEPHALOSPORINS IN RATS
- Effects of Ethanol, Acetoin and 2,3-Butanediol on EEG Power Spectra in Conscious Rats
- The Influence of the Protein Kinase A System in Differentiation of HL-60-Eo Cells to Eosinophils Induced by Histamine
- Effect of Methylcarbonylmethyl 2(S)-[4-(4-Guanidino-benzoyloxy)phenyl] Propionate Methanesulfonate (TT-S24) on Experimental Pancreatitis in Rats
- Inhibitory Effect of Levocabastine on Experimental Allergic Conjunctivitis in Guinea Pigs
- Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
- Effects of Some H_1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate-Receptor Agonist on Histamine H_1 Receptor Antagonist-Induced Memory Deficit in Rats
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water
- Hypnotic Activities of Chamomile and Passiflora Extracts in Sleep-Disturbed Rats(Pharmacology)
- Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice(Biopharmacy)
- Regulatory Machanism of Eosinophil Peroxidase Release From Guinea Pig Eosinophils
- Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells
- EFFCTS OF HISTAMINE AND ITS RELATED COMPOUNDS ON IMPAIRMENT OF PASSIVE AVOIDANCE RESPONSE FOLLOWING HIPPOCAMPAL LESIONS IN RATS
- Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance
- Effects of Antiepileptics on Lateral Geniculate Nucleus–Kindled Seizures in Rats
- INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
- CATALEPTIC EFFECT OF HISTAMINE INDUCED BY INTRAVENTRICULAR INJECTION IN MICE
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- NALOXONE-INDUCED ABSTINENCE SYNDROMES IN MORPHINE-TREATED MICE
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust
- EFFECTS OF ANTIDEPRESSANT DRUGS ON AMYGDALOID AFTER-DISCHARGE IN RATS
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION BEHAVIOR IN RATS
- The Role of lons on Histamine-lnduced Depolarization in Isolated Guinea Pig Adipocytes.
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of intraventricular injection of histamine on the pinna reflex in mice.
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Histamine-Induced Depolarization and the Cyclic AMP-Protein Kinase A System in Isolated Guinea Pig Adipocytes.
- Changes in Self-Stimulation Response during Chronic Morphine Treatment and after Withdrawal of Morphine in Rats.