Effects of the Cell Wall of Kluyveromyces marxianus YIT 8292 on the Plasma Cholesterol and Fecal Sterol Excretion in Rats Fed on a High-Cholesterol Diet
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概要
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The cellular components involved in the hypocholesterolemic activity of Kluyveromyces marxianus YIT 8292 were examined in rats fed on a high-cholesterol diet. Whole cells (KM) were heated at 115 °C for 10 minutes and fractionated into water-soluble extract 1 and the insoluble residue (KM-CW). After mechanical disruption by glass beads, KM-CW was separated into the cell wall (KM-W) and water-soluble extract 2. Plasma total cholesterol was decreased by feeding KM-CW or KM-W, but was not changed by feeding extract 1 or extract 2. Feeding KM-CW and KM-W increased the fecal sterol excretion and concentration of short-chain fatty acids (SCFA) in the cecum. The hypocholesterolemic activity of KM-CW was completely abolished by the enzymatic degradation of α-mannan and β-glucan. These results suggest that α-mannan and β-glucan were the major active components of KM, and that its hypocholesterolemic activity may be attributable to the increasing fecal sterol excretion and/or production of SCFA.
- 2005-04-23
著者
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Ito Masahiko
Yakult Central Inst. For Microbiological Res.
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Yoshida Yuki
Showa Pharmaceutical University
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SAWADA Haruji
Yakult Central Institute for Microbiological Research
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Sawada H
Yakult Central Inst. For Microbiological Res.
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Yoshida Y
Yakult Central Inst. For Microbiological Res.
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Sansawa H
Yakult Inst. Microbiological Res. Tokyo Jpn
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OHISHI Kenji
Yakult Central Institute for Microbiological Research
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YOSHIDA Yasuto
Yakult Central Institute for Microbiological Research
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YOKOI Wakae
Yakult Central Institute for Microbiological Research
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NAITO Eiichiro
Yakult Central Institute for Microbiological Research
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Ohishi K
Yakult Honsha European Research Center For Microbiology Esv
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