Influences of Histamine H_1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats(Pharmacology)
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概要
- 論文の詳細を見る
The influences of histamine H_1 receptor antagonists on maximal electroshock seizure were studied using infant rats. In this study, electroconvulsion was induced by stimulating rats using ear-clip electrodes, and the durations of electroencephalogram (EEG) seizure, tonic extensor (TE) seizure and clonic (CL) seizure induced by maximal electroshock were measured. Diphenhydramine, chlorpheniramine, cyproheptadine and ketotifen caused a dose-dependent and significant prolongation of both EEG seizure and TE seizure induced by maximal electroshock. On the other hand, epinastine and fexofenadine caused no such effects, even at a dose of 50 mg/kg. All drugs used in this study showed no significant effect on CL seizure induced by maximal electroshock. From these findings, it is suggested that epinastine and fexofenadine may cause no harmful influence on epilepsy, even when used in a little child.
- 公益社団法人日本薬学会の論文
- 2007-03-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Rahman Md.
Department Of Precision Science & Technology And Applied Physics Osaka University
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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ISHIKAWA TAKASHI
Department of Gastroenterology, Faculty of Medicine, The University of Tokyo
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Rahman Md.
Department Of Agriculture Bsmrau
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Rahman Md.
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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TAKECHI Kenshi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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AGO Jun
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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MATSUMOTO Naotaka
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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MURAKAMI Aya
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Ishikawa Takashi
Department Of Gastroenterological Surgery Yokohama City University Postgraduate School Of Medicine
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Ago Jun
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Murakami Aya
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Takechi Kenshi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Matsumoto Naotaka
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishikawa Takashi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishikawa Takashi
Department Of Breast And Thyroid Surgery Yokohama City University Medical Center
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Takechi Kenshi
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Takechi Kenshi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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ISHIKAWA Takashi
Department of Applied Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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