Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice
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概要
- 論文の詳細を見る
The changes of electromyographic activity (EMG seizure) induced by maximal electroshock were studied in comparison with those of behavioral seizures in mice. In addition, the effects of certain antiepileptics on behavioral seizures and EMG seizure induced by maximal electroshock were also studied. High amplitude with high frequency EMG seizure was observed in parallel with the appearance of tonic extensor (TE) seizure and an intimate relationship was observed between the two parameters. On the other hand, to investigate the intensity of TE seizure, the product of the amplitude and the duration in EMG seizure was calculated, and the effects of antiepileptics on the magnitude of EMG seizure were investigated. As a result, a significant difference was observed at the doses of antiepileptics that showed no significant effects on the durations of TE and EMG seizures; that is, phenytoin, phenobarbital, topiramate, and carbamazepine showed significant effects on the magnitude of EMG seizure at doses of 5, 2, 10, and 5 mg/kg, respectively. From these findings, it may be concluded that this index, that is, the magnitude of EMG seizure induced by maximal electroshock, is a more reliable and highly sensitive method for the assessment of the potential activity of antiepileptics.
- 社団法人 日本薬理学会の論文
- 2007-05-20
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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ISHIKAWA TAKASHI
Department of Gastroenterology, Faculty of Medicine, The University of Tokyo
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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TAKECHI Kenshi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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AGO Jun
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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MATSUMOTO Naotaka
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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MURAKAMI Aya
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Ishikawa Takashi
Department Of Gastroenterological Surgery Yokohama City University Postgraduate School Of Medicine
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Ago Jun
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Murakami Aya
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Takechi Kenshi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Matsumoto Naotaka
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishikawa Takashi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Ishikawa Takashi
Department Of Breast And Thyroid Surgery Yokohama City University Medical Center
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Takechi Kenshi
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Takechi Kenshi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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ISHIKAWA Takashi
Department of Applied Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
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