Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats
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概要
- 論文の詳細を見る
The present study was undertaken to investigate the effect of ethanol on the sleep-wake cycle in normal rats and sleep-disturbed rats. In normal rats, no significant difference was observed by ethanol in sleep latency, total awake time and total non-rapid eye movement (NREM) sleep time, except for total REM sleep time. On the other hand, in sleep-disturbed rats, ethanol at doses of 1 and 2 g/kg caused significant decreases in sleep latency and total wake time, and an increase in total NREM sleep time. In addition, ethanol showed a significant increase in delta activity in the sleep-disturbed model rat, different from triazolam. These results suggested that ethanol had not only a hypnotic but also a sleep-maintaining effect in sleep-disturbed rats at reasonable blood ethanol concentrations.
- 日本薬学会の論文
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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ISHIDA Takayuki
Department of Applied Physics and Chemistry, The University of Electro-Communications
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TSUTSUI Ryuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Ishida Takayuki
Department Of Applied Pharmacology Kagoshima University Graduate School Of Medical And Dental Scienc
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Obara Yoshihito
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Ishida Takayuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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