Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust(Pharmacology)
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概要
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The present study was performed to investigate the effects of histamine H_1-antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended over water, significant increases in the awake time and decreases in non-rapid eye movement (non-REM) sleep time were observed compared with in rats on sawdust, even when measured hourly for 6h. Diphenhydramine, chlorpheniramine and promethazine caused a significant decrease in the awake time and increase in non-REM sleep time in rats placed on the grid suspended over water for 1-2h and/or 2-3h after administration. On the other hand, in rats placed on sawdust, no significant differences were observed in the awake time and non-REM sleep time with diphenhydramine and chlorpheniramine compared with the control. Different from these two drugs, promethazine caused a significant decrease in the awake time and increase in non-REM sleep time 1-2h and 2-3h after administration even when rats were placed on sawdust at a relatively high dose. These results clearly indicate that histamine H_1-antagonists had potent effects on decreasing the awake time and increasing non-REM sleep time under the conditions of an activated histaminergic system.
- 公益社団法人日本薬学会の論文
- 2009-01-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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ISHIDA Takayuki
Department of Applied Physics and Chemistry, The University of Electro-Communications
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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TSUTSUI Ryuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Ishida Takayuki
Department Of Applied Pharmacology Kagoshima University Graduate School Of Medical And Dental Scienc
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Obara Yoshihito
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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TOKUNAGA Shin
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Tokunaga Shin
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Tokunaga Shin
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Ishida Takayuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Tsutsui Ryuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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