Effects of a Dictamnus dasycarpus T. Extract on Allergic Models in Mice
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概要
- 論文の詳細を見る
The anti-allergic effect of a 70% ethanol extract from Dictamnus dasycarpus Turcz (DDT) was studied in mice. DDT at doses of 200 and 500 mg/kg inhibited the systemic anaphylactic shock induced by compound 48/80 in a dose-dependent manner. It also inhibited dose-dependently the scratching behavior induced by compound 48/80, histamine and serotonin. An increase in the vascular permeability induced by compound 48/80, histamine and serotonin was also inhibited by DDT. In an in vitro study, DDT inhibited the histamine released from rat peritoneal mast cells induced by compound 48/80. It seems likely from these findings that DDT was effective in antagonizing certain pharmacological effects induced by compound 48/80 that occurred via both histamine and serotonin released from mast cells. In conclusion, DDT may be effective in the relief of symptoms of allergic atopic dermatitis and other allergy-related diseases.
- 社団法人 日本農芸化学会の論文
- 2008-03-23
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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NAKANO Yoshiyuki
Department of Applied Materials Science, Graduate School of Engineering, Osaka Prefecture University
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Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
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Nakano Yoshiyuki
Department Of Applied Materials Science Graduate School Of Engineering Osaka Prefecture University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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JIANG Shuishi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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YATSUZUKA Rie
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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RAHMAN Mohamed
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Nakano Yoshiyuki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Rahman Mohamed
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Jiang Shuishi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Yatsuzuka Rie
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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