Caffeic Acid Inhibits Compound 48/80-Induced Allergic Symptoms in Mice(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The effect of caffeic acid on scratching behavior and vascular permeability changes induced by compound 48/80 in ICR mice were investigated. An oral dose of 500mg/kg of caffeic acid significantly inhibited scratching behavior and vascular permeability induced by compound 48/80. The inhibitory effects of daily administration of lower doses of caffeic acid, 100 and 200mg/kg, were also investigated; and it was found that 200mg/kg significantly inhibited compound 48/80-induced scratching behavior after the second week of consecutive administration. The effect of 200mg/kg of caffeic acid on scratching behavior was observed up to the third week of the treatment. The decrease in histamine content induced by compound 48/80 was significantly antagonized by 200mg/kg. The findings suggest that caffeic acid may be effective for treating itch and edema in allergic dermatitis.
- 公益社団法人日本薬学会の論文
- 2006-01-01
著者
-
Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
Kamei C
岡山大学 医歯薬学総合研究科薬効解析学
-
Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
-
Kamei Chiaki
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
-
Kamei Chiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University Okayama
-
INOUE Toshio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
-
Minami Kazuhisa
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
FUJII Yoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
-
Inoue T
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University:ogawa & Co. Ltd
-
Fujii Yoko
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
-
Fujii Yoko
Department Of Environmental Science For Human Life Faculty Of Agriculture Shizuoka University
-
Inoue Toshio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Hossen Maria
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
-
SHINMEI Yoshifumi
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
-
Inoue Toshio
Dep. Of Pharmacotherapy Nihon Pharmaceutical Univ.
-
Shinmei Yoshifumi
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
-
Fujii Yoko
Department Of Agriculture And Horticulture Kobe University
-
Inoue Toshio
Department Of Cardiology Yufuin Kohseinenkin Hospital
-
Inoue Toshio
Material R&d Laboratory Ogawa & Co. Ltd.
関連論文
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate–Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats
- Participation of Prostaglandin E2 Receptor in Nasal Congestion of Brown Norway Rats
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- Interaction between Hippocampal γ-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats
- Anticonvulsant Effect of (RS)-1-Aminoindan-1,5-dicarboxylic Acid on Pentetrazol-Induced Kindled Seizures in Mice
- Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
- Effects of Peppermint (Mentha piperita L.) Extracts on Experimental Allergic Rhinitis in Rats
- SUPPRESSION OF VENTRICULAR PREMATURE CONTRACTIONS CONTINUES AFTER THE WASHOUT OF ANTIARRHYTHMIC DRUGS
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- Participation of GABAergic and Histaminergic Systems in Inhibiting Amygdaloid Kindled Seizures
- Slow Wave Sleep-inducing Effects of First Generation H_1-Antagonists
- Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia
- 4 Recovery Phase Admission Type Cardic Rehabilitation Program. Importance of the Network System with Acute Phase and Recovery Phase Rehabilitation Facilities(Cardiac Rehabilitation Therapy at the Chronic Stage, The 71st Annual Scientific Meeting of the Ja
- Preparation and Characterization of Two Crystalline Forms of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159)
- Synthesis and Pharmacological Activity of 4-Amino-5-chloro-2-methoxy-N-[(2S, 4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159) and Its Optical Isomers
- Development of Amygdaloid Kindling in Histidine Decarboxylase-deficient and Histamine H_1 Receptor-deficient Mice
- Determination of TF Subtypes in Human Organ Tissues Using Isoelectric Focusing and Immunoblotting
- Effect of Ethanol on Sleep-Awake State in Sleep-Disturbed Rats
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust(Pharmacology)
- Chemical Constituents of Coreopsis lanceolata L. and Their Physiological Activities
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Genotyping of the N-acetyltransferase2 Polymorphism in the Prediction of Adverse Drug Reactions to Isoniazid in Japanese Patients
- High Throughput Detection of Drug-Metabolizing Enzyme Polymorphisms by Allele-Specific Fluorogenic 5' Nuclease Chain Reaction Assay
- Detection Assay of Rare Variants of the Thiopurine Methyltransferase Gene by PCR-RFLP Using a Mismatch Primer in a Japanese Population
- Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice
- Embryogenic Callus Induction from Coffea arabica Leaf Explants by Benzyladenine
- Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
- HEART RATE-DEPENDENT ALTERATION OF THE FREQUENCY AND COUPLING INTERVAL OF VENTRICULAR ARRHYTHMIAS AS MEASURED BY 24-HOUR ECG MONITORING
- -120-THE CHANGE OF VENTRICULAR PREMATURE CONTRACTIONS AFTER ANTIARRHYTHMIC DRUG DISCONTINUATION : Cardiovascular Drugs : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Participation of the Cholinergic System in Ameliorating Effect of Vasopressin Fragment by Group I Metabotropic Glutamate-Receptor Blockade
- Influences of Histamine H_1 Receptor Antagonists on Maximal Electroshock Seizure in Infant Rats(Pharmacology)
- Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats(Pharmacology)
- Evaluation of Anxiolytic-like Effects of Some Short-Acting Benzodiazepine Hypnotics in Mice
- Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns
- Participation of Histamine H_3 Receptors in Experimental Allergic Rhinitis of Mice
- The Effects of Selective Serotonin-Reuptake Inhibitor on Visual Evoked Potential in Rats
- Comparative Study of Certain Antibiotics on Epileptogenic Property, Including (1Rpi, 5S, 6S)-2-[(6,7-Dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)] thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate (LJC10627), a Carbapenem Antibiotic wit
- Brief Communications Transcatheter closure of congenital ventricular septal defects in 3 dogs using a detachable coil (平成15年麻布大学公的研究助成金事業研究成果報告)
- Mechanism of the Inhibitory Effect of Histamine on Amygdaloid-Kindled Seizures in Rats
- Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
- Characterization of ASK Mice, a Strain Highly Sensitive to Anaphylactic Shock
- Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice
- Role of Substance P on Histamine H_3 Antagonist-Induced Scratching Behavior in Mice
- Caffeic Acid Inhibits Compound 48/80-Induced Allergic Symptoms in Mice(Pharmacology)
- Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
- Influences of Everninomicin, Vancomycin and Teicoplanin on Chemical Mediator Release From Rat Peritoneal Mast Cells
- Increasing Effect by Simultaneous Use of Levocabastine and Pemirolast on Experimental Allergic Conjunctivitis in Rats(Pharmacology)
- DIFFERENTIAL ANTAGONISM OF ANTIAVOIDANCE, CATALEPTIC AND PTOTIC EFFECTS OF NEUROLEPTICS BY BIPERIDEN
- EFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE
- cDNA Cloning of Radish (Raphanus sativus) Myrosinase and Tissue-Specific Expression in Root
- cDNA CLONING OF RADISH MYROSINASE
- Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
- Effects of Histidine on Working Memory Deficits Induced by the 5-HT_-Receptor Agonist 8-OH-DPAT
- Effect of Propolis Extract on D-Galactosamine-Induced Hepatic Injury in Rats
- Mechanism of Bradykinin-Induced Histamine Release from Rat Peritoneal Mast Cells
- Effects of Anti-dementia Drugs on Morphine-Induced Somnolence
- Effects of Hop Extracts on Nasal Rubbing and Sneezing in BALB/c Mice(Pharmacology)
- Effects of Antiepileptics on Lateral Geniculate Nucleus-Kindled Seizures in Rats
- Effects of a Dictamnus dasycarpus T. Extract on Allergic Models in Mice
- Effects of Various Antiepileptics on Behavioral and Electroencephalographic Seizures Induced by Maximal Electroshock in Mice
- Inhibitory Effects of Moutan Cortex on Immediate Allergic Reactions(Pharmacology)
- Effect of Usuhiratake (Pleurotus pulmonarius) on Sneezing and Nasal Rubbing in BALB/c Mice(Pharmacology)
- Effects of Certain Antiepileptics on Behavioral and Electromyographic Seizure Patterns Induced by Maximal Electroshock in Mice
- Characteristics of Scratching Behavior Induced by Some Chemical Mediators in Hairless Mice
- Antipruritic and Antierythema Effects of Ascomycete Bulgaria inquinans Extract in ICR Mice(Pharmacology)
- Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on Nasal Rubbing and Scratching Behavior in ICR Mice(Pharmacology)
- Effects of Cholinergic Drugs and Cerebral Metabolic Activators on Memory Impairment in Old Rats
- EPILEPTOGENIC ACTIVITY INDUCED BY INTRAVENOUS INJECTION OF CERTAIN CEPHALOSPORINS IN RATS
- Effects of Ethanol, Acetoin and 2,3-Butanediol on EEG Power Spectra in Conscious Rats
- The Influence of the Protein Kinase A System in Differentiation of HL-60-Eo Cells to Eosinophils Induced by Histamine
- Effect of Methylcarbonylmethyl 2(S)-[4-(4-Guanidino-benzoyloxy)phenyl] Propionate Methanesulfonate (TT-S24) on Experimental Pancreatitis in Rats
- Inhibitory Effect of Levocabastine on Experimental Allergic Conjunctivitis in Guinea Pigs
- Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
- Effects of Some H_1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats
- Ameliorative Effect of a Hippocampal Metabotropic Glutamate-Receptor Agonist on Histamine H_1 Receptor Antagonist-Induced Memory Deficit in Rats
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of Tandospirone on Sleep Latency in Rats Placed on a Grid Suspended Over Water
- Hypnotic Activities of Chamomile and Passiflora Extracts in Sleep-Disturbed Rats(Pharmacology)
- Effects of Lactobacillus acidophilus Strain L-55 on Experimental Allergic Rhinitis in BALB/c Mice(Biopharmacy)
- Regulatory Machanism of Eosinophil Peroxidase Release From Guinea Pig Eosinophils
- Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells
- EFFCTS OF HISTAMINE AND ITS RELATED COMPOUNDS ON IMPAIRMENT OF PASSIVE AVOIDANCE RESPONSE FOLLOWING HIPPOCAMPAL LESIONS IN RATS
- Effect of Histamine on Muscimol-Induced Working Memory Deficits in Radial Maze Performance
- Effects of Antiepileptics on Lateral Geniculate Nucleus–Kindled Seizures in Rats
- INFLUENCE OF HISTAMINE AND RELATED COMPOUNDS ON THE HYPNOTIC EFFECT OF THIOPENTAL IN MICE
- CATALEPTIC EFFECT OF HISTAMINE INDUCED BY INTRAVENTRICULAR INJECTION IN MICE
- SIGNIFICANCE OF WITHDRAWAL JUMPING RESPONSE IN PREDICTING PHYSICAL DEPENDENCE IN MICE
- NALOXONE-INDUCED ABSTINENCE SYNDROMES IN MORPHINE-TREATED MICE
- Patent Ductus Arteriosus Ligation in Two Young Cats with Pulmonary Hypertension
- Effects of Histamine H_1-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust
- EFFECTS OF ANTIDEPRESSANT DRUGS ON AMYGDALOID AFTER-DISCHARGE IN RATS
- EFFECTS OF PSYCHOTROPIC DRUGS ON HYPOTHALAMIC SELF-STIMULATION BEHAVIOR IN RATS
- The Role of lons on Histamine-lnduced Depolarization in Isolated Guinea Pig Adipocytes.
- Potentiation of Ethanol in Spatial Memory Deficits Induced by Some Benzodiazepines
- Effect of intraventricular injection of histamine on the pinna reflex in mice.
- Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice
- Histamine-Induced Depolarization and the Cyclic AMP-Protein Kinase A System in Isolated Guinea Pig Adipocytes.
- Changes in Self-Stimulation Response during Chronic Morphine Treatment and after Withdrawal of Morphine in Rats.