Brief Communications Transcatheter closure of congenital ventricular septal defects in 3 dogs using a detachable coil (平成15年麻布大学公的研究助成金事業研究成果報告)

概要

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The purpose of this study was to evaluate the feasibility, safety, and efficacy of transcatheter closure in dogs with a congenital perimembranous ventricular septal defect (VSD) using a detachable coil. No dogs showed any symptoms, and chest X-ray and ECG were normal. The diameters of VSD ranged from 2 to 4mm on echocardiogram. The defect was 2 to 2.5mm from the aortic valve. A detachable coil (size 5mm with 5 loops) designed for patent ductus arteriosus (PDA) was delivered via the transarterial route. The device was successfully employed in all dogs. A minimal residual shunt was observed in all dogs even though Qp/Qs decreased. Hemolysis and a rate-dependent right-bundle branch block were observed in 1 dog, but there was no clinical significance. No major complication was noted. Pathological examination after 1 year revealed that the coils were covered with tissue without significant damage to the His-Purkinje conduction system. In conclusion, transcatheter closure of a small perimembranous VSD using a detachable coil can be achieved without major complications or significant pathological damage at the lesion site.
麻布大学の論文