Postnatal Changes in the Rheological Properties of the Aorta in Sprague-Dawley Rats
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概要
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Postnatal changes in the rheological properties of the aortic wall were investigated in relation to morphological development of the wall in Sprague-Dawley (SD) rats at 3, 8 and 20 weeks old. The mechanical tensile characteristics of the longitudinal wall strip excised from the proximal thoracic aorta were assessed with stress-strain and stress-relaxation tests. Wall tension in the low and medium strain ranges was significantly lower in 3-week-old rats than in 8-week-old rats and in 8-week-old rats than in 20-week-old rats. Wall stress was significantly lower in 3-week-old rats than in 8- and 20-week-old rats mainly in the medium strain range, but was significantly greater in 3-week-old rats than in 8- and 20-week-old rats in the high strain range. The value of incremental elastic modulus at 3 weeks old was significantly smaller than that at 8 and 20 weeks old at a strain of 0.25 and significantly larger than that at 8 and 20 weeks old at a strain of 0.50. The value of relaxation strength at 5 min after the stretching was significantly greater at 3 weeks old than that at 8 and 20 weeks old. The wall was viscoelastic in the low and medium strain ranges at 3 weeks though large wall stress was generated in the high strain range. Histological investigation revealed that the smooth muscle layer, fine elastin fiber connecting thick elastin fibers and wall thickness were thin at 3 weeks old in comparison with those at 8 and 20 weeks old, though there was no significant difference in number of nuclei of the smooth muscle cells among the three age groups. Changes in the tensile characteristics of the wall reflected well those of the microstructure of the wall with growth. The rheological properties and microstructure of the aortic wall were close to maturation at 8 weeks in SD rats.
- 社団法人 日本実験動物学会の論文
著者
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SHIMIZU Tsuyoshi
Department of Cardiothoracic Surgery, The University of Tokyo
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WAKI Hidefumi
Department of Physiology, Wakayama Medical University, School of medicine
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Kimura Shuichi
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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Shimizu Tsuyoshi
Shimizu Institute Of Space Physiology Suwa Maternity Clinic
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Shimizu Tsuyoshi
福島県立医科大学 医学部生理学
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KATSUDA Shin-ichiro
Department of Physiology, Fukushima Medical University School of Medicine
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Machida Noboru
Department Of Veterinary Clinical Oncology Faculty Of Agriculture Tokyo University Of Agriculture An
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Machida Noboru
Department Of Veterinary Pathology Faculty Of Agriculture Tokyo University Of Agricukture And Techno
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Kimura Shuichi
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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YAMASAKI Masao
Department of Cellular and Integrative Physiology, Fukushima Medical University School of Medicine
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KATAHIRA Kiyoaki
Experimental Animal Research Center Fukushima Medical University School of Medicine
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O-ISHI Hirotaka
Department of Physiology, Fukushima Medical University School of Medicine
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NAGAYAMA Tadanori
Department of Physiology, Fukushima Medical University School of Medicine
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HASEGAWA Masamitsu
National Cardiovascular Center Research Institute
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Katsuda S
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Kimura S
Laboratory Of Nutrition Graduate School Of Agricultural Science Tohoku University
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Waki Hidefumi
Department Of Physiology Fukushima Medical University School Of Medicine
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Yamasaki Masao
Department Of Cellular And Integrative Physiology Fukushima Medical University School Of Medicine
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Katsuda Shin-ichi
Department Of Biological Safety Research Tama Laboratory Japan Food Research Laboratories
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Katsuda Shin-ichiro
Department Of Cellular And Integrative Physiology School Of Medicine Fukushima Medical University
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki
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Shimizu T
Shimizu Institute Of Space Physiology Suwa Maternity Clinic
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Shimizu Tsuyoshi
Department Of Cardiothoracic Surgery The University Of Tokyo
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Katahira Kiyoaki
Experimental Animal Center Fukushima Medical University School Of Medicine
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Nagayama Tadanori
Department Of Physiology Fukushima Medical University School Of Medicine
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Yamasaki Masao
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University
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O-ishi Hirotaka
Department Of Physiology Fukushima Medical University School Of Medicine
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Kamiyama Shin
Gene Research Center Tohoku University
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