Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes

スポンサーリンク

概要

• 論文の詳細を見る

• The dietary effects of conjugated linoleic acid (CLA) on Ig production of Sprague-Dawley rats were examined at various doses such as 0 (control), 0.05,0.10,0.25,and 0.50%. CLA increased IgG and IgM production of spleen lymphocytes in a dose-dependent manner, and these levels reached a plateau at 0.25%. IgA production was not detected in the control group, while it was detected in all CLA-fed groups and IgA productivity of spleen lymphocytes increased in a dose-dependent manner at the doses from 0.05 to 0.50%. Dietary CLA did not affect serum Ig levels. The major fatty acid composition of spleen lymphocytes was not affected by dietary CLA, which itself was hardly incorporated into the cells. In an in vitro assay, the effects of CLA and its oxidative derivatives, furan type fatty acids, on Ig productivity were also examined. As a result, 100μM CLA suppressed Ig production of spleen lymphocytes and the degree was as follows IgA>IgG>IgM. Each CLA isomer and the furan type fatty acids also suppressed Ig production but the degree was weaker than the mixture of CLA isomers. In this result, dietary CLA increased Ig productivity of spleen lymphocytes in vivo.

• 社団法人日本農芸化学会の論文
• 2000-10-23

著者

• Sugano Michihiro

  Faculty of Agriculture, Kyushu University

• Yamashita Masahiro

  Department Of Bioengineering Tokyo Institute Of Technology

• KASAI Michio

  The Nisshin OilliO Group, Ltd.

• Yamada Koji

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University

• YAMADA Koji

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky

• TACHIBANA Hirofumi

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Ky

• Tachibana H

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Tachibana Hirofumi

  九州大学 農学部生物機能化学食糧化学

• Tachibana Hirofumi

  Graduate School Of Genetic Resources Technology Kyushu University

• Yamada Koji

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Sugano M

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Sugano M

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sakono M

  Laboratory Of Nutrition Chemistry Faculty Of Agriculture Graduate School Of Kyushu University

• Yazawa K

  九州大学 農学部生物機能化学食糧化学

• YAMASAKI Masao

  Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and

• Sugano M

  Kumamoto Prefectural Univ. Kumamoto Jpn

• Sugano Michihiro

  Faculty Of Environmental And Symbiotic Science Prefectural University Of Kumamoto

• Sugano Michihiro

  Fac. Of Environmental And Symbiotic Sciences Prefectural Univ. Of Kumamoto

• Sugano Michihiro

  Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture

• Kasai M

  The Nisshin Oillio Group Ltd.

• MANSHO Keiko

  Laboratory of Food Chemistry, Institute of Applied Biological Chemistry, Department of Bioscience an

• KISHIHARA Koji

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Division of Bioresource an

• OGINO Yuuya

  Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Division of Bioresource an

• KASAI Masaaki

  Nagoya Factory, Rinol Oil Mills, Co., Ltd.

• Miyazaki Yoshiyuki

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Tachibana Hirofumi

  Department Of Food Science And Technology Faculty Of Agriculture Kyushu University

• Tachibana Hirofumi

  Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Kasai Michio

  The Nisshin Oillio Group Ltd.

• Sugano M

  Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K

• Yamada K

  Laboratory Of Food Chemistry Division Of Applied Biological Chemistry Department Of Bioscience And B

• Ogino Yuuya

  Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Murao Kayoko

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Mansho Keiko

  Laboratory Of Food Chemistry Institute Of Applied Biological Chemistry Department Of Bioscience And

• Kishihara Koji

  Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• Yamasaki Masao

  Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture University Of Miyazaki

• Miyazaki Y

  Dep. Of Life Sci. Graduate School Of Bioscience And Biotechnology Tokyo Inst. Of Technol.

• Yamasaki Masao

  Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University

• Tian Huaize

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Kyushu University

• Yamada Koji

  Laboratopy Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And

• TACHIBANA Hirofumi

  Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University

関連論文

• Hepatic Function and Lipid Metabolism Are Modulated by Short-term Feeding of Cholesterol Oxidation Products in Rats
• S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans II. Structure Elucidation
• Selective Induction of Interleukin-1 Production and Tumor Killing Activity of Macrophages Through Apoptosis by the Inhibition of Oxidative Respiration
• Suppression of T Cell Stimulating Function of Allogeneic Antigen Presenting Cells by Prodigiosin 25-C
• Immunosuppressive Activity of Streptonigrin in Vitro and in Vivo
• Prodigiosin 25-C Perturbs Permeation of Acetate in a Cultured Cell Line
• Presentation of Exogenous Antigen by Macrophages But Not by Spleen Cells Is Inhibited by Leupeptin and Antipain
• Development and Characterization of Macrophage Hybridomas Derived from Murine Peritoneal Exudate Cells
• Effects of Microbial Products on Glucose Consumption and Morphology of Macrophages
• Melastin, a Novel Product of Streptomyces That Selectively Inhibits Leukemia Cell Growth
• Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin
• Effects of L-156,602,a C5a Receptor Antagonist, on Mouse Experimental Models of Inflammation
• Preferential Suppression of Delayed-type Hypersensitivity by L-156,602,a C5a Receptor Antagonist
• A Novel in Vivo Screening Method for Immunomodulating Substances : Development of an Assay System
• Multidrug Resistance Phenotype Conferred by Overexpressing bfr2^+/pad1^+/sks1^+or pap1^+Genes and Mediated by bfr1^+Gene Product, a Structural and Functional Homologue of P-Glycoprotein in Schizosaccharomyces pombe
• Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
• Characterization of a Novel Fungal Protein, p15, Which Induces Neuronal Differentiation of PC12 Cells
• S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans I. Producing Strain, Fermentation, Isolation and Biological Activity
• Identification and Characterization of Porcine NP-190, a Novel Protein That Is Specifically Expressed in the Axonal Membrane during the Embryonic Period^1
• Isolation and Characterization of a 230 kDa Protein(p230) Specifically Expressed in Fetal Brains: Its Involvement in Neurite Outgrowth from Rat Cerebral Cortex Neurons Grown on Monolayer of Astrocytes
• The Gene Responsible for Tunicamycin Resistance, tmrB, in Bacillus subtilis(Microbilolgy & Fermentation Industry)
• Pressure Effects on an S = 1 Haldane Compound Ni(C_5H_N_2)_2N_3(PF_6)
• Pressure Effects on an S=1 Haldane Compound Ni(C_5H_N_2)_2N_3(PF_6)
• Folimycin (Concanamycin A), a Specific Inhibitor of V-ATPase, Blocks Intra-cellular Translocation of the Glycoprotein of Vesicular Stomatitis Virus before Arrival to the Golgi Apparatus
• Construction of New ARSI Vectors with Increased Mitotic Stability in Saccharomyces cerevisiae(Microbiology & Fermentation Industry)
• Mutational Site in Tunicamycin-resistant Mutation tmrB8 of Bacillus subtilis as Revealed at the Nucleotide Sequence Level(Microbiology & Fermentation Industry)
• Efficacies of Different Secretion Vectors for Secretion of Human Epidermal Growth Factor by Escherichia coli(Biological Chemistry)
• recE-Dependent Gene Amplification Induced by a Tunicamycin-resistant Mutation (tmrA7) in Bacillus subtilis(Microbiology & Fermentation Industry)
• Expression and Secretion of Human Epidermal Growth Factor in Escherichia coli(Microbiology & Fermentation Industry)
• Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
• Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo
• Magnetic-Field-Induced Freezing of Spin Correlations in Networked System of [Mn_4] Single-Molecule Magnets(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Two-Dimensional Coordination Networks of [Mn_4] Single-Molecule Magnets : Heat Capacity Measurements(Condensed matter : structure and mechanical and thermal properties)
• Evaluation of Insulin Permeability and Effects of Absorption Enhancers on Its Permeability by an in Vitro Pulmonary Epithelial System Using Xenopus Pulmonary Membrane
• Systematic Synthesis of Porphyrin Dimers Linked by Conjugated Oligoacetylene Bridges
• Pyrene-Fused Porphyrins : Annulation Reactions of meso-Pyrenylporphyrins
• Effect of Dietary Fats and Sesamin on the Lipid Metabolism and Immune Function of Sprague-Dawley Rats
• Raman Scattering by Ethylenediamines in Quasi-One-Dimensional Mixed-Valence Complexes [M (en)_2][Pt (en)_2Cl_2](ClO_4)_4(M=Pt,Pd,en=ethylenediamine)
• Combined Effects of Dietary Protein Type and Fat Level on the Body Fat-Reducing Activity of Conjugated Linoleic Acid (CLA) in Rats
• A Square Cyclic Porphyrin Dodecamer : Synthesis and Single-Molecule Characterization
• Tuning of Electronic Structures of Quasi-One-Dimensional Bromo-Bridged Pd^-Pd^ Mixed-Valence Complexes by Substituting Counter Anions
• Versatile Vapochromic Behavior Accompanied by a Phase Change between Charge-Polarization State and Charge-Density-Wave State in a Quasi-One-Dimensional Iodo-Bridged Dinuclear Platinum Mixed-Valence Compound, [{NH_3(CH_2)_5NH_3}_2]-[Pt_2(pop)_4I]・4H_2O
• Metal-Metal Bonded Diruthenium Unit Axial-Capped by Di-tert-butylphenolate : [Ru_2(O_2CCH_3)_2(t-Busal-R'py)_2]^- (t-Busal-R'py^ = N-(R'-2-pyridyl)-2-oxido-3,5-di-tert-butylbenzylaminato ; R' = H, 4-Me, and 5-Me)
• New Charge-transfer Salts Based on Unsymmetrical Donor DMET and Metal Complex Anions : (DMET)_3[Cr(isoq)_2(NCS)_4] and (DMET)_3[Cr(phen)(NCS)_4]・CH_3CN
• Synthesis and Structural Determination of a Porphyrinatoplatinum(II) : meso-Tetrakis(4-t-butylphenyl)porphyrinatoplatinum(II)
• 23pWX-6 Scanning Tunneling Microscopy Investigation of tris(phthalocyaninato)yttrium triple-decker molecules deposited on Au(111)
• Reduced Expression of Perchloric Acid-Soluble Protein after Partial Hepatectomy in Rats
• Oxidative Stress by Visible Light Irradiation Suppresses Immunoglobulin Production in Mouse Spleen Lymphocytes
• Development of Assay System for Immunoglobulin Production Regulatory Factors using Whole Cell Cultures of Mouse Splenocytes
• Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes
• Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats
• Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
• Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice(Food & Nutrition Science)
• Effect of Dietary Level of Pectin on Immunoglobulin and Cytokine Production by Mesenteric Lymph Node Lymphocytes and Interleukin-2 Receptor in Rats
• Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats(Food & Nutrition Science)
• Defect in Cell Wall Integrity of the Yeast Saccharomyces cerevisiae Caused by a Mutation of the GDP-mannose Pyrophosphorylase Gene VIG9
• Molecular Characterization of a Novel Yeast Cell-wall Acid Phosphatase Cloned from Kluyveromyces marxianus
• Measurement of Total and Food Component-Specific IgA in Human Saliva
• Effect of Oxidized Cholesterol on Age-associated Changes to Immune Parameters in Spleen Lymphocytes and Peritoneal Exudate Cells Derived from Rats
• Synthesis, Structure, and Reactivities of the η^1:η^6-μ_2-Aryl Alkynyl Diruthenium Complex. X-Ray Structure of [CP(PPh_3)_2Ru(η^1:η^6-μ_2-C≡CC_6H_4Me-p)RuCp*]PF_6(Cp=η_5-C_5H_5, Cp*=η_5-C_5Me_5)
• A Surface-Silylated Single-Layer Resist Using Chemical Amplification for Deep Ultraviolet Lithography:II. Limited Permeation of Si Compounds from Liquid Phase^* : Instrumentation, Measurement, and Fabrication Technology
• Combined Effects of Dietary Conjugated Linoleic Acid and Sesamin on Triacylglycerol and Ketone Body Production in Rat Liver
• Purification and Characterization of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) Derivatives : KW-2228 and Other Derivatives
• Syntheses, Crystal Structure, and Magnetic Properties of Mn_ Single-Molecule Magnets with Naphthalenecarboxylate Bridges, [Mn_O_(O_2CC_H_7)_(H_2O)_4] and Their Tetraphenyl-phosphonium Salts
• Effect of Dietary Sesamin on Metabolic Fate of an Exogenous Linolelaidic Acid in Perfused Rat Liver
• Effects of Nonthermal Processes on the Inactivation of Microorganisms and Antioxidants in Minimally Processed Vegetables
• Metal Valence Structures and Magnetic Interactions in Halogen-Bridged 1-D Ni-Pd Mixed-Metal Complexes Studied by ^C and ^1H Solid State NMR
• Ultrafast Optical Responses in a One-Dimensional Mott Insulator of a Br-Bridged Ni Compound(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Ultrafast Photoconversion from Charge Density Wave State to Mott-Hubbard State in One-Dimensional Extended Peierls-Hubbard System of Br-Bridged Pd Compound(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Construction of a One-Dimensional Chain Composed of Mn_6 Clusters and 4,4'-Bipyridine Linkers: The First Step for Creation of "Nono-Dots-Wires"
• Pressure Effect of an S=1 Haldane Compound NDMAZ : Condensed Matter: Electronic Properties, etc.
• A Novel Mn_ Single-molecule Magnet with a μ_3-Methanesulfonate Bridge
• A Chemical Modification of a Mn_ Single-Molecule Magnet by Replacing Carboxylate Anions with Diphenylphosphate Anions
• Trans Fatty Acids in Margarines Marketed in Eleven Countries
• Study of trans Fatty Acid Content in Commercial Foods in Japan: 4.Chocolate and Chocolate Confectioery 〔和文〕
• Biofilm formation by Escherichia coli in hypertonic sucrose media(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• High-Hydrostatic-Pressure Treatment Impairs Actin Cables and Budding in Saccharomyces cerevisiae (MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• High Hydrostatic Pressure Treatment Impairs AcrAB-TolC Pump Resulting in Differential Loss of Deoxycholate Tolerance in Escherichia coli(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Estimation of the Biofilm Formation of Escherichia coli K-12 by the Cell Number(Environmental Biotechnology)
• High Pressure Carbon Dioxide Decreases the Heat Tolerance of the Bacterial Spores
• Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli(Microbiology & Fermentation Technology)
• Effect of High Pressure Gaseous and Supercritical Carbon Dioxide Treatments on Bacterial Spores
• KJ1 Development of Neu-up, a Human G-CSF Derivative with Higher Specific Activity
• Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis in Sprague-Dawley Rats Fed Saturated and Polyunsaturated Triacylglycerols and Diacylglycerols
• Dietary Restriction Downregulates Free Radical and Lipid Peroxide Production : Plausible Mechanism for Elongation of Life Span
• Mixed-Species Biofilm Formation by Direct Cell-Cell Contact between Brewing Yeasts and Lactic Acid Bacteria
• Ferromagnetic Assemblies Composed of Mn^ Salen-Type Complexes and a Tripodal Fe^ Complex with an Imidazolate Bridge
• Effects of Dietary Soybean Peptides on Hepatic Production of Ketone Bodies and Secretion of Triglyceride by Perfused Rat Liver
• Cytoplasmic Acidification May Occur in High-Pressure Carbon Dioxide-Treated Escherichia coli K12
• Cell-Cycle Independent Chromosome Condensation in Schizosaccharomyces pombe Induced by High Hydrostatic Pressure Treatment
• Cessation of Cytokinesis in Schizosaccharomyces pombe during Growth after Release from High Hydrostatic Pressure Treatment
• Tuning of Electronic Structures of Quasi-One-Dimensional Halogen-Bridged Ni-Pd Mixed-Metal Complexes, [Ni_ Pd_x(chxn)_2 X]X_2 (X = Cl, Br) with Strong Electron Correlation
• Structures and Magnetic Properties of Dinuclear Copper(II) Complexes Containing a Bulky Diamine Ligand, 1,2-Dipiperidinoethane
• One-dimensional Halogen-bridged Ni^ Compounds : Chemistry and Physics in Strongly Correlated Electron Systems
• Combined Effects of Dietary Conjugated Linoleic Acid and Sesamin on Triacylglycerol and Ketone Body Production in Rat Liver
• Low-Temperature Scanning Tunneling Microscopy Investigation of Tris(phthalocyaninato)yttrium Triple-Decker Molecules Deposited on Au(111)
• Balanced Intake of Polyunsaturated Fatty Acids for Health Benefits
• Temperature- and Pressure-Induced Charge-Density-Wave to Mott--Hubbard Phase Transitions in Quasi-One-Dimensional Bromine-Bridged Pd Compounds
• Studies on mixed valence complexes of platinum and palladium. I. Preparation and characterization of Pt(II)-Pt(IV), Pd(II)-Pt(IV), and Pd(II)-Pd(IV) complexes of the general formula, [M(AA)2][M'X2(AA)2]Y4.
• Studies on mixed valence complexes of platinum and palladium. II. The crystal structures of [Pt(tn)2][PtCl2(tn)2](BF4)4, [Pt(tn)2][PtBr2(tn)2](ClO4)4, and [Pt(tn)2][PtBr2(tn)2](BF4)4.

もっと見る 閉じる

スポンサーリンク