Melastin, a Novel Product of Streptomyces That Selectively Inhibits Leukemia Cell Growth

スポンサーリンク

概要

• 論文の詳細を見る

• In the course of our screening for new immunomodulators, a novel compound, melastin, was purified from the culture broth of Streptomyces. Melastin was purified through adsorption to Diaion HP-20, ethanol precipitation, and anion exchange column as a brown powder. The molecular weight was estimated as 5000±3000 by gel filtration HPLC. Melastin suppressed lipopolysaccharide (LPS)-induced blastogenesis of B cells more profoundly than concanavalin A (con A)- or phytohemagglutinin (PHA)-induced blastogenesis of T cells. Moreover, it selectively inhibited the growth of several leukemia cells as compared with interleukin-dependent nontransformed leukocytes. No selectivity was observed between nontransformed fibroblasts and their oncogene-transformed variants. Melastin did not selectively inhibit macromolecule synthesis of leukemia cells.

• 社団法人日本農芸化学会の論文
• 1993-06-23

著者

• Magae Junji

  Radiation Safety Research Center, Central Institute of Electric Power Industry

• Yamasaki M

  Department Of Biotechnology The University Of Tokyo:(present Address)department Of Food Science And

• Yamashita Masahiro

  Department Of Bioengineering Tokyo Institute Of Technology

• HANADA Toshihiko

  Department of Biotechnology, The University of Tokyo

• KATAOKA Takao

  Department of Bioengineering, Tokyo Institute of Technology

• YAMASAKI Makari

  Department of Agricultural Chemistry, the University of Tokyo

• MAGAE Junji

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• LEE Mi-heon

  Department of Bioengineering, Tokyo Institute of Technology

• Wang Zhang

  Department of Agricultural Chemistry, The University of Tokyo

• Uramoto Masakazu

  RIKEN, The Institute of Physical and Chemical Research

• Tsuji F.Ryohei

  Department of Agricultural Chemistry, The University of Tokyo

• Kurisaki Tomohiro

  Department of Agricultural Chemistry, The University of Tokyo

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Hanada T

  Univ. Tokyo Tokyo Jpn

• Hanada Toshihiko

  Department Of Biotechnology The University Of Tokyo

• Kataoka T

  Tokyo Inst. Technol. Yokohama Jpn

• Kataoka Takao

  東京工業大学

• Uramoto M

  Riken (the Institute Of Physical And Chemical Research)

• Uramoto M

  Tamagawa Univ. Tokyo Jpn

• Uramoto M

  Department Of Applied Biological Chemistry Tamagawa University

• Kudo T

  Inst. Physical And Chemical Res. (riken) Saitama Jpn

• Ueki Masashi

  Riken Institute

• URAMOTO Masakazu

  The Institute of Physical and Chemical Research

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University Tamagawa Gakuen

• Yamasaki Makari

  Advanced Research Institute For The Science And Humanities Nihon University

• Yamasaki Makari

  Department Of Agricultural Chemistry The University Of Tokyo

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• Uramoto Masakazu

  Riken (the Institute Of Physical And Chemical Research)

• Kataoka Takao

  Department Of Bioengineering Tokyo Institute Of Technology

• Lee M‐h

  Department Of Bioengineering Tokyo Institute Of Technology

• Wang Zhang

  Department Of Agricultural Chemistry The University Of Tokyo

• Tsuji F.ryohei

  Department Of Agricultural Chemistry The University Of Tokyo

• Lee Mi-heon

  Department Of Bioengineering Tokyo Institute Of Technology

• Kataoka Takao

  Department Of Applied Biology Kyoto Institute Of Technology

関連論文

• Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP(MEDICAL BIOTECHNOLOGY)
• S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans II. Structure Elucidation
• Selective Induction of Interleukin-1 Production and Tumor Killing Activity of Macrophages Through Apoptosis by the Inhibition of Oxidative Respiration
• Suppression of T Cell Stimulating Function of Allogeneic Antigen Presenting Cells by Prodigiosin 25-C
• Immunosuppressive Activity of Streptonigrin in Vitro and in Vivo
• Prodigiosin 25-C Perturbs Permeation of Acetate in a Cultured Cell Line
• Presentation of Exogenous Antigen by Macrophages But Not by Spleen Cells Is Inhibited by Leupeptin and Antipain
• Development and Characterization of Macrophage Hybridomas Derived from Murine Peritoneal Exudate Cells
• Effects of Microbial Products on Glucose Consumption and Morphology of Macrophages
• Melastin, a Novel Product of Streptomyces That Selectively Inhibits Leukemia Cell Growth
• Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin
• Effects of L-156,602,a C5a Receptor Antagonist, on Mouse Experimental Models of Inflammation
• Preferential Suppression of Delayed-type Hypersensitivity by L-156,602,a C5a Receptor Antagonist
• A Novel in Vivo Screening Method for Immunomodulating Substances : Development of an Assay System
• Multidrug Resistance Phenotype Conferred by Overexpressing bfr2^+/pad1^+/sks1^+or pap1^+Genes and Mediated by bfr1^+Gene Product, a Structural and Functional Homologue of P-Glycoprotein in Schizosaccharomyces pombe
• Characterization of a Novel Fungal Protein, p15, Which Induces Neuronal Differentiation of PC12 Cells
• S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans I. Producing Strain, Fermentation, Isolation and Biological Activity
• Identification and Characterization of Porcine NP-190, a Novel Protein That Is Specifically Expressed in the Axonal Membrane during the Embryonic Period^1
• Isolation and Characterization of a 230 kDa Protein(p230) Specifically Expressed in Fetal Brains: Its Involvement in Neurite Outgrowth from Rat Cerebral Cortex Neurons Grown on Monolayer of Astrocytes
• Hop-Resistant Lactobacillus brevis Contains a Novel Plasmid Harboring a Multidrug Resistance-Like Gene
• TmrB Protein, Which Confers Resistance to Tunicamycin on Bacillus subtilis, Binds Tunicamycin
• The Gene Responsible for Tunicamycin Resistance, tmrB, in Bacillus subtilis(Microbilolgy & Fermentation Industry)
• Pressure Effects on an S = 1 Haldane Compound Ni(C_5H_N_2)_2N_3(PF_6)
• Pressure Effects on an S=1 Haldane Compound Ni(C_5H_N_2)_2N_3(PF_6)
• Folimycin (concanamycin A) and Bafilomycin A_1, Inhibitors Specific for V-ATPase,Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins
• Folimycin (Concanamycin A), a Specific Inhibitor of V-ATPase, Blocks Intra-cellular Translocation of the Glycoprotein of Vesicular Stomatitis Virus before Arrival to the Golgi Apparatus
• PPARγ Activation and Adipocyte Differentiation Induced by AS-6, a Prenyl-phenol Antidiabetic Antibiotic
• Induction of Two Types of Gene Amplification by a Cloned DNA Fragment and Amplification of a Foreign Gene on the Bacillus subtilis Chromosome by Using the Fragment
• Amplification of an Integration Plasmid Introduced into the tmr A Amplification Unit of A Bacillus subtitis Tunicamycin-resistant Mutant
• Construction of New ARSI Vectors with Increased Mitotic Stability in Saccharomyces cerevisiae(Microbiology & Fermentation Industry)
• Mutational Site in Tunicamycin-resistant Mutation tmrB8 of Bacillus subtilis as Revealed at the Nucleotide Sequence Level(Microbiology & Fermentation Industry)
• Efficacies of Different Secretion Vectors for Secretion of Human Epidermal Growth Factor by Escherichia coli(Biological Chemistry)
• Substrate Specificity of Acid Proteinase A from Aspergillus niger var. macrosporus
• Novel Saccharomyces cerevisiae Temperature-sensitive cyrl Mutant Which Accumulates Glycogen Particles
• recE-Dependent Gene Amplification Induced by a Tunicamycin-resistant Mutation (tmrA7) in Bacillus subtilis(Microbiology & Fermentation Industry)
• Expression and Secretion of Human Epidermal Growth Factor in Escherichia coli(Microbiology & Fermentation Industry)
• Sequence of the Signal Peptide of E. coli Alkaline Phosphatase
• Structure-Activity Relationship within a Series of Degradation Products of Tautomycin
• Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats
• Dose-Dependent Effect of Dietary Conjugated Linoleic Acid on the Growth of Rat Hepatoma dRLh-84 Cells In Vivo
• Magnetic-Field-Induced Freezing of Spin Correlations in Networked System of [Mn_4] Single-Molecule Magnets(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Two-Dimensional Coordination Networks of [Mn_4] Single-Molecule Magnets : Heat Capacity Measurements(Condensed matter : structure and mechanical and thermal properties)
• Evaluation of Insulin Permeability and Effects of Absorption Enhancers on Its Permeability by an in Vitro Pulmonary Epithelial System Using Xenopus Pulmonary Membrane
• Systematic Synthesis of Porphyrin Dimers Linked by Conjugated Oligoacetylene Bridges
• Pyrene-Fused Porphyrins : Annulation Reactions of meso-Pyrenylporphyrins
• Fas Ligand Released by Activated Monocytes Causes Apoptosis of Lung Epithelial Cells in Human Acute Lung Injury Model in Vitro(Molecular and Cell Biology)
• Identification of Low Molecular Weight Probes on Perforin- and Fas-based Killing Mediated by Cytotoxic T Lymphocytes
• Costunolide and Dehydrocostus Lactone as Inhibitors of Killing Function of Cytotoxic T LymPhocytes
• 1'-Acetoxychavicol Acetate as an Inhibitor of Phagocytosis of Macrophages
• Prodigiosin 25-C Suppression of Cytotoxic T Cells in Vitro and in Vivo Similar to That of Concanamycin B, a Specific Inhibitor of Vacuolar Type H^+-ATPase
• Screening for Specific Inhibitors of Phagocytosis of Thioglycollate-elicited Macrophages
• Raman Scattering by Ethylenediamines in Quasi-One-Dimensional Mixed-Valence Complexes [M (en)_2][Pt (en)_2Cl_2](ClO_4)_4(M=Pt,Pd,en=ethylenediamine)
• Molecular Cloning of a Gene, DHS1, Which Complements a Drug-hypersensitive Mutation of the Yeast Saccharomyces cerevisiae
• Aberrant Expression of Fra-1 in Estrogen Receptor-negative Breast Cancers and Suppression of their Propagation In Vivo by Ascochlorin, an Antibiotic that Inhibits Cellular Activator Protein-1 Activity
• A Square Cyclic Porphyrin Dodecamer : Synthesis and Single-Molecule Characterization
• Tuning of Electronic Structures of Quasi-One-Dimensional Bromo-Bridged Pd^-Pd^ Mixed-Valence Complexes by Substituting Counter Anions
• Versatile Vapochromic Behavior Accompanied by a Phase Change between Charge-Polarization State and Charge-Density-Wave State in a Quasi-One-Dimensional Iodo-Bridged Dinuclear Platinum Mixed-Valence Compound, [{NH_3(CH_2)_5NH_3}_2]-[Pt_2(pop)_4I]・4H_2O
• Metal-Metal Bonded Diruthenium Unit Axial-Capped by Di-tert-butylphenolate : [Ru_2(O_2CCH_3)_2(t-Busal-R'py)_2]^- (t-Busal-R'py^ = N-(R'-2-pyridyl)-2-oxido-3,5-di-tert-butylbenzylaminato ; R' = H, 4-Me, and 5-Me)
• New Charge-transfer Salts Based on Unsymmetrical Donor DMET and Metal Complex Anions : (DMET)_3[Cr(isoq)_2(NCS)_4] and (DMET)_3[Cr(phen)(NCS)_4]・CH_3CN
• Synthesis and Structural Determination of a Porphyrinatoplatinum(II) : meso-Tetrakis(4-t-butylphenyl)porphyrinatoplatinum(II)
• 23pWX-6 Scanning Tunneling Microscopy Investigation of tris(phthalocyaninato)yttrium triple-decker molecules deposited on Au(111)
• Reduced Expression of Perchloric Acid-Soluble Protein after Partial Hepatectomy in Rats
• Oxidative Stress by Visible Light Irradiation Suppresses Immunoglobulin Production in Mouse Spleen Lymphocytes
• Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes
• Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats
• Immunosuppressive Activity of 4-O-Methylascochlorin
• Elimination of Cell-cycle Regulators during Caspase-3-dependent Apoptosis Caused by an Immunosuppressant, FTY720(Biochemistry & Molecular Biology)
• Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice(Food & Nutrition Science)
• Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats(Food & Nutrition Science)
• Defect in Cell Wall Integrity of the Yeast Saccharomyces cerevisiae Caused by a Mutation of the GDP-mannose Pyrophosphorylase Gene VIG9
• Molecular Characterization of a Novel Yeast Cell-wall Acid Phosphatase Cloned from Kluyveromyces marxianus
• Distinct Interaction of TmrB Protein with Membranes in Bacillus subtilis and Escherichia coli
• Synthesis, Structure, and Reactivities of the η^1:η^6-μ_2-Aryl Alkynyl Diruthenium Complex. X-Ray Structure of [CP(PPh_3)_2Ru(η^1:η^6-μ_2-C≡CC_6H_4Me-p)RuCp*]PF_6(Cp=η_5-C_5H_5, Cp*=η_5-C_5Me_5)
• A Surface-Silylated Single-Layer Resist Using Chemical Amplification for Deep Ultraviolet Lithography:II. Limited Permeation of Si Compounds from Liquid Phase^* : Instrumentation, Measurement, and Fabrication Technology
• Cloning Genomic DNA Encoding Apple Polyphenol Oxidase and Comparison of the Gene Product in Escherichia coli and in Apple
• Purification and Characterization of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) Derivatives : KW-2228 and Other Derivatives
• Syntheses, Crystal Structure, and Magnetic Properties of Mn_ Single-Molecule Magnets with Naphthalenecarboxylate Bridges, [Mn_O_(O_2CC_H_7)_(H_2O)_4] and Their Tetraphenyl-phosphonium Salts
• Effects of Nonthermal Processes on the Inactivation of Microorganisms and Antioxidants in Minimally Processed Vegetables
• Metal Valence Structures and Magnetic Interactions in Halogen-Bridged 1-D Ni-Pd Mixed-Metal Complexes Studied by ^C and ^1H Solid State NMR
• Ultrafast Optical Responses in a One-Dimensional Mott Insulator of a Br-Bridged Ni Compound(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Ultrafast Photoconversion from Charge Density Wave State to Mott-Hubbard State in One-Dimensional Extended Peierls-Hubbard System of Br-Bridged Pd Compound(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
• Construction of a One-Dimensional Chain Composed of Mn_6 Clusters and 4,4'-Bipyridine Linkers: The First Step for Creation of "Nono-Dots-Wires"
• Pressure Effect of an S=1 Haldane Compound NDMAZ : Condensed Matter: Electronic Properties, etc.
• A Novel Mn_ Single-molecule Magnet with a μ_3-Methanesulfonate Bridge
• A Chemical Modification of a Mn_ Single-Molecule Magnet by Replacing Carboxylate Anions with Diphenylphosphate Anions
• Biofilm formation by Escherichia coli in hypertonic sucrose media(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• High-Hydrostatic-Pressure Treatment Impairs Actin Cables and Budding in Saccharomyces cerevisiae (MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• High Hydrostatic Pressure Treatment Impairs AcrAB-TolC Pump Resulting in Differential Loss of Deoxycholate Tolerance in Escherichia coli(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Estimation of the Biofilm Formation of Escherichia coli K-12 by the Cell Number(Environmental Biotechnology)
• High Pressure Carbon Dioxide Decreases the Heat Tolerance of the Bacterial Spores
• Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli(Microbiology & Fermentation Technology)
• Effect of High Pressure Gaseous and Supercritical Carbon Dioxide Treatments on Bacterial Spores
• Cladribine Enhances Apoptotic Cell Death in Lung Carcinoma Cells Over-Expressing DNase γ
• KJ1 Development of Neu-up, a Human G-CSF Derivative with Higher Specific Activity
• Mixed-Species Biofilm Formation by Direct Cell-Cell Contact between Brewing Yeasts and Lactic Acid Bacteria
• Ferromagnetic Assemblies Composed of Mn^ Salen-Type Complexes and a Tripodal Fe^ Complex with an Imidazolate Bridge
• Cytoplasmic Acidification May Occur in High-Pressure Carbon Dioxide-Treated Escherichia coli K12
• Cell-Cycle Independent Chromosome Condensation in Schizosaccharomyces pombe Induced by High Hydrostatic Pressure Treatment
• Cessation of Cytokinesis in Schizosaccharomyces pombe during Growth after Release from High Hydrostatic Pressure Treatment
• Improved Production and Recovery of Alkaline Elastase from Alkalophilic Bacillus Strain by a Change of Medium Composition

もっと見る 閉じる

スポンサーリンク