Identification of Low Molecular Weight Probes on Perforin- and Fas-based Killing Mediated by Cytotoxic T Lymphocytes
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概要
- 論文の詳細を見る
Perforin- and Fas-based killing pathways are two major mechanisms of cytotoxic T lymphocytes (CTL)-mediated cytotoxicity. In this paper, we have reported the identification of low molecular weight probes on CTL-mediated cytolysis. In addition to inhibitors of acidification so far reported, three other groups of compounds have been identified to block perforin-based cytolysis by the CD8^+ CTL clone: (1) an inhibitor of actin polymerization (cytochalasin D), (2) respiratory inhibitors (antimycin A and oligomycin A), and (3) protein kinase inhibitors (calphostin C, herbimycin A, K252a, and staurosporine). Since Fas-based cytolysis by CD4^+ CTL clone was inhibitable or rather increased by these agents, only vacuolar type H^+-ATPase inhibitors such as concanamycin A have been shown to be highly specific probes to block perforin-based CTL-mediated cytotoxicity.
- 社団法人日本農芸化学会の論文
- 1996-10-23
著者
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Magae Junji
Radiation Safety Research Center, Central Institute of Electric Power Industry
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山田 晃
東京農工大学生物システム応用科学府
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KATAOKA Takao
Department of Bioengineering, Tokyo Institute of Technology
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MAGAE Junji
Department of Bioengineering, Tokyo Institute of Technology
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NAGAI Kazuo
Department of Bioengineering, Tokyo Institute of Technology
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SUZUKI Hidefumi
Department of Bioengineering, Tokyo Institute of Technology
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Magae J
Tokyo Inst. Technol. Yokohama Jpn
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Magae Junji
京都府立医科大学 麻酔学
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Magae Junji
Dep. Of Biotechnology Inst. Of Res. And Innovation
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Magae Junji
Radiation Safety Research Center Central Institute Of Electric Power Industry
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Magae J
Inst. Res. And Innovation Kashiwa Jpn
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Kataoka T
Tokyo Inst. Technol. Yokohama Jpn
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Kataoka Takao
東京工業大学
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Yamada Atsushi
Department of Cardiology, Juntendo University School of Medicine
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Hamada S
Department Of Bioengineering Tokyo Institute Of Technology
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Hamada Shin-ichi
Department Of Bioengineering Tokyo Institute Of Technology
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Kudo T
Inst. Physical And Chemical Res. (riken) Saitama Jpn
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Nagai K
Yamanouchi Pharmaceutical Co. Ltd. Tokyo Jpn
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Nagai Kazuo
Department Of Applied Biological Chemistry Chubu University
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Nagai K
Chubu Univ. Aichi Jpn
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TANIGUCHI Masatoshi
Department of Bioengineering, Tokyo Institute of Technology
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Kataoka Takao
Department Of Bioengineering Tokyo Institute Of Technology
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Taniguchi Masatoshi
Department Of Applied Biology Kyoto Institute Of Technology
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Suzuki H
Kirin Brewery Co. Ltd. Takasaki Jpn
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Yamada Atsushi
Department Of Cardiology Juntendo University School Of Medicine
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Kataoka Takao
Department Of Applied Biology Kyoto Institute Of Technology
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YAMADA Atsushi
Department of Biochemistry, Showa University School of Dentistry
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YAMADA ATSUSHI
DEPARTMENT OF ADMINISTRATION ENGINEERING CHUO UNIVERSITY
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