Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity

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概要

• 論文の詳細を見る

• Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans : the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8^+ CTL clone at IC_<50> values of 30 μM and 50 μM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.

• 公益社団法人日本薬学会の論文
• 1997-09-15

著者

• 山田 晃

  東京農工大学生物システム応用科学府

• YOSHIDA Takashi

  Faculty of Pharmaceutical Sciences, Matsuyama University

• KATAOKA Takao

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Kataoka T

  Tokyo Inst. Technol. Yokohama Jpn

• Kataoka Takao

  東京工業大学

• Yamada Atsushi

  Department of Cardiology, Juntendo University School of Medicine

• Hamada S

  Department Of Bioengineering Tokyo Institute Of Technology

• Hamada Shin-ichi

  Department Of Bioengineering Tokyo Institute Of Technology

• Kudo T

  Inst. Physical And Chemical Res. (riken) Saitama Jpn

• NISHIMURA Toshio

  Department of Pathology, Kansai Medical University

• Nagai K

  Yamanouchi Pharmaceutical Co. Ltd. Tokyo Jpn

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• OTAKE Noboru

  Department of Biosciences, School of Science and Engineering, Teikyo University

• WOO Je-Tae

  Department of Bioengineering, Tokyo Institute of Technology

• Kataoka Takao

  Department Of Bioengineering Tokyo Institute Of Technology

• Woo Je-tae

  Dep. Of Biological Chemistry Chubu Univ.

• Woo J‐t

  Chubu Univ. Aichi Jpn

• Woo Je-tae

  Department Of Applied Biological Science Tokyo Noko University

• Woo Je-tae

  Sagami Chemical Research Center

• Woo Je-tae

  Department Of Bioengineering Tokyo Institute Of Technology

• Otake Noboru

  Department Of Science And Technology Teikyo University

• Nakae Takashi

  Biochemical Research Laboratory Ezaki Glico Co. Ltd.

• Nishimura T

  Biochemical Research Laboratory Ezaki Glico Co. Ltd.

• Yoshida Takashi

  Faculty Of Agriculture Kyusyu University

• Otake Noboru

  Department Of Biosciences Teikyo University

• Nishimura Toshio

  Department Of Pathology Kansai Medical University

• Nishimura Toshio

  Department Of Communication Engineering Osaka University

• Yoshida Takashi

  Faculty Of Agriculture And Life Science Hirosaki University

• Yamada Atsushi

  Department Of Cardiology Juntendo University School Of Medicine

• Kataoka Takao

  Department Of Applied Biology Kyoto Institute Of Technology

• Nishimura Toshio

  Department Of Biosciences School Of Science And Engineering Teikyo University

• YAMADA Atsushi

  Department of Biochemistry, Showa University School of Dentistry

• YAMADA ATSUSHI

  DEPARTMENT OF ADMINISTRATION ENGINEERING CHUO UNIVERSITY

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