Immunosuppressive Activity of Streptonigrin in Vitro and in Vivo
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概要
- 論文の詳細を見る
The immune system is composed of various cells with distinct functions. Thus, highly selective immunomodulators are necessary for artificial regulation of immune reactions. We screened microbial products for such immunomodulators and we identified streptonigrin as a selective suppressor of B-cell proliferation induced by lipopolysaccharide. Streptonigrin directly suppressed the late phase of proliferation of B-cells. The inhibition of topoisomerase II was implicated as the mechanism of the B-cell-selective suppression. In cultured cell lines, however, streptonigrin preferentially suppressed the growth of an interleukin-3-dependent myeloid cell line rather than B-cell lines. In addition, the treatment with streptonigrin in vivo suppressed T-cells more significantly than B-cells and dramatically reduced the spleen weight. These results suggest that streptonigrin preferentially suppresses myeloid T-cell precursors in vivo.
- 社団法人日本農芸化学会の論文
- 1996-05-23
著者
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Magae Junji
Radiation Safety Research Center, Central Institute of Electric Power Industry
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Yamasaki M
Department Of Biotechnology The University Of Tokyo:(present Address)department Of Food Science And
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Yamashita Masahiro
Department Of Bioengineering Tokyo Institute Of Technology
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KATAOKA Takao
Department of Bioengineering, Tokyo Institute of Technology
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MAGAE Junji
Department of Bioengineering, Tokyo Institute of Technology
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NAGAI Kazuo
Department of Bioengineering, Tokyo Institute of Technology
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SUZUKI Hidefumi
Department of Bioengineering, Tokyo Institute of Technology
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LEE Joey
Department of Bioengineering, Tokyo Institute of Technology
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Magae J
Tokyo Inst. Technol. Yokohama Jpn
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Magae Junji
京都府立医科大学 麻酔学
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Magae Junji
Dep. Of Biotechnology Inst. Of Res. And Innovation
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Magae Junji
Radiation Safety Research Center Central Institute Of Electric Power Industry
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Magae J
Inst. Res. And Innovation Kashiwa Jpn
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Kataoka T
Tokyo Inst. Technol. Yokohama Jpn
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Kataoka Takao
東京工業大学
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Kudo T
Inst. Physical And Chemical Res. (riken) Saitama Jpn
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Yamasaki Makari
Advanced Research Institute For The Science And Humanities Nihon University
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Nagai K
Yamanouchi Pharmaceutical Co. Ltd. Tokyo Jpn
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Nagai Kazuo
Department Of Applied Biological Chemistry Chubu University
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Nagai K
Chubu Univ. Aichi Jpn
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Kataoka Takao
Department Of Bioengineering Tokyo Institute Of Technology
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Suzuki H
Kirin Brewery Co. Ltd. Takasaki Jpn
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Lee Joey
Department Of Bioengineering Tokyo Institute Of Technology
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Kataoka Takao
Department Of Applied Biology Kyoto Institute Of Technology
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