Preferential Suppression of Delayed-type Hypersensitivity by L-156,602,a C5a Receptor Antagonist

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概要

• 論文の詳細を見る

• In the course of our screening for in vivo immunomodulating substances in which sheep red blood cells (SRBC) and heat-killed Brucella abortus cells (thymus dependent and independent antigens, respectively) for antibody production assays, and trinitrobenzene sulfonic acid (TNBS) for delayed-type hypersensitivity (DTH) assay were adopted as antigens, we detected a DTH-specific suppressive activity. The producing organism was isolated from a soil sample collected in Ushiku City, Ibaraki, Japan and identified with Streptomyces sp. A1502 (FERM P-12448). The active component was identified with L-156,602,a C5a receptor antagonist. L-156,602 suppressed both TNBS-induced and TNP-SRBC-induced DTH while it enhanced antibody production against SRBC, Brucella abortus, and TNP-SRBC. L-156,602 significantly suppressed DTH induced by direct injection of type 1 helper T cells and its relevant antigen into hindfootpads, indicating that the efferent phase of DTH was affected by L-156,602. The results demonstrated that L-156,602 preferentially suppressed the DTH response.

• 社団法人日本農芸化学会の論文
• 1992-10-23

著者

• Yamasaki M

  Department Of Biotechnology The University Of Tokyo:(present Address)department Of Food Science And

• Yamashita Masahiro

  Department Of Bioengineering Tokyo Institute Of Technology

• YAMASAKI Makari

  Department of Agricultural Chemistry, the University of Tokyo

• MAGAE Junji

  Department of Bioengineering, Tokyo Institute of Technology

• NAGAI Kazuo

  Department of Bioengineering, Tokyo Institute of Technology

• Tsuji Ryohei

  Department of Agricultural Chemistry, the University of Tokyo

• URAMOTO Masakazu

  Division of Molecular Characterization, RIKEN (The Institute of Physical and Chemical Research)

• KOSHINO Hiroyuki

  Division of Molecular Characterization, RIKEN (The Institute of Physical and Chemical Research)

• TSUJI Noriko

  National Institute of Animal Industry

• Magae J

  Tokyo Inst. Technol. Yokohama Jpn

• Magae Junji

  京都府立医科大学 麻酔学

• Magae Junji

  Dep. Of Biotechnology Inst. Of Res. And Innovation

• Magae Junji

  Radiation Safety Research Center Central Institute Of Electric Power Industry

• Magae J

  Inst. Res. And Innovation Kashiwa Jpn

• Uramoto M

  Riken (the Institute Of Physical And Chemical Research)

• Uramoto M

  Tamagawa Univ. Tokyo Jpn

• Uramoto M

  Department Of Applied Biological Chemistry Tamagawa University

• Ueki Masashi

  Riken Institute

• URAMOTO Masakazu

  The Institute of Physical and Chemical Research

• Uramoto Masakazu

  Faculty Of Agriculture Tamagawa University Tamagawa Gakuen

• Yamasaki Makari

  Advanced Research Institute For The Science And Humanities Nihon University

• Yamasaki Makari

  Department Of Agricultural Chemistry The University Of Tokyo

• Nagai Kazuo

  Department Of Applied Biological Chemistry Chubu University

• Nagai K

  Chubu Univ. Aichi Jpn

• Koshino H

  Riken (the Inst. Physical And Chemical Res.) Saitama Jpn

• Koshino Hiroyuki

  Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University:(present Address) Ri

• Koshino Hiroyuki

  Molecular Characterization Characterization Center Riken(the Institute Of Physical And Chemical Rese

• Tsuji R

  Noda Inst. Scientific Res. Chiba Jpn

• Koshino Hiroyuki

  Advanced Science Institute Riken

• Tsuji Ryohei

  Department of Agricultrual Chemistry, The University of Tokyo

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