Epiderstatin and Its Related Glutarimide Antibiotics Inhibit the Cell Growth Induced by Mitogen Stimulation(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the immunosuppressive effects of glutarimide antibiotics including a new antibiotic named epiderstatin, we tested these antibiotics for inhibition of the blastogenesis of mouse spleen cells induced by mitogen stimulation (concanavalin A or lipopolysaccharide). The inhibitory activity was measured by colorimetric MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. Among the glutarimide antibiotics tested, epiderstatin and acetoxycycloheximide especially strongly inhibited the blastogenesis of mouse spleen cells induced by concanavalin A and lipopolysaccharide, however, selectivity between T and B lymphocytes was not observed.
- 社団法人日本農芸化学会の論文
- 1990-05-23
著者
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OSADA Hiroyuki
Antibiotics Laboratory, Discovery Research institute, RIKEN
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MAGAE Junji
Department of Bioengineering, Tokyo Institute of Technology
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Magae J
Tokyo Inst. Technol. Yokohama Jpn
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Magae J
Inst. Res. And Innovation Kashiwa Jpn
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Isono K
Inst. Physical And Chemical Res. Saitama Jpn
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Osada H
Antibiotics Laboratory Advanced Science Institute Riken
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ISONO Kiyoshi
The Institute of Physical and Chemical Research, RIKEN
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ISONO Kiyoshi
Antibiotics Laboratory, RIKEN (The Institute of Physical and Chemical Research)
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SONODA Tadamichi
Antibiotics Laboratory, RIKEN, The Institute of Physical and Chemical Research
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Isono K
The Institute Of Physical And Chemical Research Riken
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Isono Kiyoshi
Antibiotics Laboratory Riken (the Institute Of Physical And Chemical Research)
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Isono Kiyoshi
The Institute Of Physical And Chemical Research(riken)
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Isono Kiyoshi
The Institute Of Physical And Chemical Research (riken):(present Address) Department Of Marine Scien
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Osada Hiroyuki
Antibiotic Laboratory Riken (institute Of Physical And Chemical Research)
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Sonoda Tadamichi
The Institute Of Physical And Chemical Research (riken):(present Address) Riken Vitamin Co. Ltd.
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SONODA TOMOHIKO
Amase Institute, Hayashibara Biochemical Laboratories, Inc.
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Isono K
Tokai Univ. Shimizu Jpn
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