Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia coli Y-10(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Liposidomycin C (C_<42>H_<67>N_5O_<21>S, M.W. 1009) is a novel nucleoside antibiotic containing uracil, a sulfated aminosugar, and a fatty acid. It is a specific inhibitor of peptidoglycan synthesis of bacteria, inhibiting the formation of the lipid intermediates from uridine 5'-diphospho-N-acetylmuramyl-L-alanyl-D-glutamyl-meso-diaminopimelyl-D-[^<14>C]alanyl-D-[^<14>C]alanine and uridine 5'-diphospho-N-acetylglucosamine with a particulate enzyme from Escherichia coli Y-10. It also inhibited the formation of MurNAc(-pentapeptide)-P-P-lipid in the absence of UDP-GlcNAc. On the other hand, it inhibited the activity of N-acetylglucosamine transglycosylase and peptidoglycan transglycosylase only weakly using the same system from E. coli. Thus, it is concluded that the site of action of liposidomycin C is phospho-N-acetylmuramyl-pentapeptide transferase in peptidoglycan synthesis.
- 社団法人日本農芸化学会の論文
- 1989-07-23
著者
-
KIMURA Ken-ichi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
-
ISONO Kiyoshi
The Institute of Physical and Chemical Research, RIKEN
-
IZAKI Kazuo
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
-
MIYATA Nobuo
Research Institute of Life Science
-
KAMIO Yoshiyuki
Department of Applied Microbiology, Graduate School of Agricultural Science, Tohoku University
-
Isono Kiyoshi
The Institute Of Physical And Chemical Research
-
KAWANISHI Gosei
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
-
Kawanishi Gosei
Research Institute Of Life Science Snow. Brand Milk Products Co. Ltd.
-
Kawanishi Gosei
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
-
Izaki Kazuo
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
-
Izaki Kazuo
Department Of Agricultural Chemistry Tohoku University
-
Kimura K
Research Institute Of Life Science
-
Kamio Yoshiyuki
Department Of Agricultural Chemistry Tohoku University
-
Kimura K
Hokkaido Univ. Education Iwamizawa Jpn
-
Kimura Ken-ichi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
関連論文
- Morphological Changes and Reorganization of Actinfilaments in Human Myeloid Leukemia Cells Induced by a Novel Protein Phosphatase Inhibitor, Tautomycin
- New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces
- Selective Inhibition of the Bacterial Peptidoglycan Biosynthesis by the New Types of Liposidomycins
- New Types of Liposidomycins that Inhibit Bacterial Peptidoglycan Synthesis and are Produced by Streptomyces II. Isolation and Structure Elucidaion
- New Types of Liposidomycins that Inhibit Bacterial Peptdoglycan Synthesis and are Produced by Streptomyces I. Producing Organism and Medium Components
- Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment
- Structure-Activity Relationship within a Series of Degradation Products of Tautomycin
- Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergillus fumigatus
- Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus
- RS-22A, B and C:New Macrolide Antibiotics from Streptomyces violaceusniger I.Taxonomy, Fermentation, Isolation and Biological Activities
- Epiderstatin Induces the Flat Reversion of NRK Cells Transformed by Temperature-sensitive Rous Sarcoma Virus
- Isoxazole-4-carboxylic Acid as a Metabolite of Streptomyces sp. and Its Herbicidal Activity(Biological Chemistry)
- New Pyrrolobenzodiazepine Antibiotics, RK-1441A and B : II. Isolation and Structure(Organic Chemistry)
- Epiderstatin and Its Related Glutarimide Antibiotics Inhibit the Cell Growth Induced by Mitogen Stimulation(Biological Chemistry)
- Synthesis and Biological Activity of Aminoacyl Analogs of Ascamycin(Organic Chemistry)
- Xanthostatin, a New Antibiotic(Biological Chemistry)
- New Antibiotics, Albopeptins A and B
- Studies on the Mode of Action of Antlermicin A on Bacillus subtHis
- Fatty Acids as Inhibitors of Microbial Cell Wall Synthesis
- SNA-60-367 Components, New Peptide Enzyme Inhibitors of Aromatase : Structure of the Fatty Acid Side Chain and Amino Acid Sequence by Mass Spectrometry
- Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora : II. Determination of Chemical Structure
- New Types of Liposidomycins Produced by Streptomyces that Inhibit Bacterial Peptidoglycan Synthesis Structure Elucidation of Fatty Acid Components by Tandem Mass Spectrometry
- SNA-60-367, New peptide Enzyme Inhibitors against Aromatase
- Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora I. Fermentation, Isolation and Biological Properties
- SNA-8073-B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase I. Fermentation, Isolation and Biological Properties
- New Piericidin Antibiotics, 7-Demethylpiericidin A_1 and 7-Demethyl-3'-rhamnopiericidin A_1
- Further Study on the Two Pivotal Parts of Hlg2 for the Full Hemolytic Activity of Staphylococcal γ-Hemolysin
- Sequential Binding of Staphylococcal γ-Hemolysin to Human Erythrocytes and Complex Formation of the Hemolysin on the Cell Surface
- Essential Binding of LukF of Staphylococcal γ-Hemolysin Followed by the Binding of HγII for the Hemolysis of Human Erythrocytes
- An N-terminal Region of LukF of Staphylococcal Leukocidin/γ-Hemolysin Crucial for the Biological Activity of the Toxin
- Panton-Valentine Leukocidin Genes in a Phage-like Particle Isolated from Mitomycin C-Treated Staphylococcus aureus V8 (ATCC 49775)
- Production and Properties of Pectin Lyase in Pseudomonas marginalis Induced by Mitomycin C(Microbiology & Fermentation Industry)
- Enzymological and Immunological Properties of Pectin Lyases from Bacteriocinogenic Strains of Erwinia carotovora
- Molecular Properties and Activity of a Carboxyl-Terminal Truncated Form of Xylanase 3 from Aeromonas caviae W-61
- Gene of LukF-PV-like Component of Panton-Valentine Leukocidin in Staphylococcus aureus P83 is Linked with lukM
- Substitution of Lysine for Arginine in the N-Terminal 217th Amino Acid Residue of the HγII of Staphylococcal γ-Hemolysin Lowers the Activity of the Toxin
- Improved Method for Purification of Leukocidin and Gamma-Hemolysin Components from Staphylococcus aureus
- Liposidolide A, a New Antifungal Macrolide Antibiotic
- Liposidomycin C Inhibits Phospho-N-acetylmuramyl-pentapeptide Transferase in Peptidoglycan Synthesis of Escherichia coli Y-10(Biological Chemistry)
- Confirmation of the Relative Stereochemistry at C-23 and C-24 of Tautomycin
- Purification and Properties of a New Restriction Endonuclease, MxaI, from Myxococcus xanthus F18E(Biological Chemistry)
- Polyoxin N, a New Member of the Polyoxin Family
- Increase in Enzyme Activities in Embryonic Axes of Soybean Seeds during Germination(Biological Chemistry)
- Cloning, Expression, and Transglycosylation Reaction of Paenibacillus sp. Strain W-61 Xylanase 1
- Inactivation of γ-Hemolysin HγII Component by Addition of Monosialoganglioside G_ to Human Erythrocyte
- Isolation and Properties of New Photosynthetic Bacteria Isolated from Seawater
- Purification and Properties of β-1,4-Xylanases 2 and 3 from Aeromonas caviae W-61
- Purification and Properties of Acid Phosphatases from Axes and Cotyledons of Germinating Soybeans(Biological Chemistry)
- 3TA5-05 黄色ブドウ球菌の2成分性毒素γヘモリジンが形成するヘテロヘプタマー膜孔複合体の立体構造解析(蛋白質-構造,第47回日本生物物理学会年会)
- Molecular Cloning and Sequence Analysis of the Gene Encoding the Collagenase from Cytophaga sp. L43-1 Strain
- Purification and Properties of Collagenase from Cytophaga sp. L43-1 Strain
- SNF-4794: New Enzyme Inhibitors Produced by Chaetomella sp.
- ( ±) : cis : 2 : Methylspiro[1,3 : oxathiolane : 5,3' : quinuclidine] Hydrochloride, Hemihydrate (SNI : 2011, Cevimeline Hydrochloride) Induces Saliva and Tear Secretions in Rats and Mice: The Role of Muscarinic Acetylcholine Receptors
- Cloning, Nucleotide Sequence, and Disruption of Streptococcus mutans Glutathione Reductase Gene (gor)
- Molecular Cloning and Sequence Analysis of the Gene Encoding the H_2O-forming NADH Oxidase from Streptococcus mutans
- Non-Woven Fabrics as New Cell Matrices for IMR-90 Human Embryonic Lung Diploid Fibroblast Cells
- Biological Activities of Anthracycline Antibiotic SN-07 Chromophore and SN-07 Chromophore-DNA Complexes(Biological Chemistry)
- Random Point Mutation Analysis of the Signal Peptide Cleavage Area of Bacillus stearothermophilus α-Amylase(Microbiology & Fermentation Industry)
- Specific Binding of SN-07 Chromophore, an Anthracycline Antibiotic, to DNA(Biological Chemistry)
- Reconstruction of the Macromolecular Antitumor Antibiotic SN-07 from SN-07 Chromophore and DNA(Biological Chemistry)
- Microbial Polyhydroxylation of Progesterone by Acremonium strictum
- Microbial Production of Two New Dihydroxylated Androstenedione Derivatives by Acremonium strictum
- Staurosporine, a Prolyl Endopeptidase Inhibitor(Biological Chemistry)
- Borrelidin Inhibits a Cyclin-dependent Kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae
- Enzymatic Properties of an Extracellular Quinoprotein, Enacyloxin Oxidase
- An Extracellular Quinoprotein Oxidase That Catalyzes Conversion of Enacyloxin IVa to Enacyloxin IIa
- Growth of Non-Sulfur Purple Photosynthetic Bacteria under High Temperature
- Gamma-Hemolysin Genes in the Same Family with LukF and lukS Genes in Methicillin Resistant Staphylococcus aureus
- Phosphorylation of LukS by Protein Kinase A is Crucial for the LukS-Specific Function of the Staphylococcal Leukocidin on Human Polymorphonuclear Leukocytes
- Prolyl Endopeptidase Inhibitors Derived from Actinomycetes
- Molecular Cloning and Sequencing of the Extracellular Pectate Lyase II Gene from Erwinia carotovora Er
- Cloning and Characterization of the Pectate Lyase III Gene of Erwinia carotovora Er(Microbiology & Fermentation Industry)
- Purification and Properties of Pectate Lyase III of Evwinia carotovora Er(Microbiology & Fermentation Industry)
- Molecular Cloning and Sequence Analysis of the Gene Encoding the H_2O_2-forming NADH Oxidase from Streptococcus mutans
- Production of Molecular Hydrogen by a Semi-continuous Outdoor Culture of Rhodopseudomonas sphaeroides(Microbiology & Fermentation Industry)
- A Prolyl Endopeptidase Inhibitor, Propeptin Production in the Various Microbispora sp.
- Production, Purification, and Properties of a Pectin Lyase from Pseudomonas marginalis N6301
- Expression of a Pectin Lyase Gene in Escherichia coli from Pseudomonas marginalis N6301
- Analysis of Promoter Region of the Pectin Lyase Gene from Erwinia carotovora Er
- Molecular Cloning and Nucleotide Sequence of the Pectate Lyase Gene from Pseudomonas marginalis N6301
- Essential Residues, W177 and R198, of LukF for Phosphatidylcholine-Binding and Pore-Formation by Staphylococcal γ-Hemolysin on Human Erythrocyte Membranes
- Treatment of Lipid-Containing Wastewater Using Bacteria Which Assimilate Lipids
- The Structure of Enacyloxin II, a Novel Linear Polyenic Antibiotic Produced by Gluconobacter sp. W-315(Organic Chemistry)
- Purification and Characterization of a Thermostable Neutral Metalloprotease I from Chloroflexus aurantiacus J-10-fl
- Application of Electroporation for Transformation in Erwinia carotovora(Microbiology & Fermentation Industry)
- Cloning, Expression, and Transglycosylation Reaction of Paenibacillus sp. Strain W-61 Xylanase 1
- Occurrence of Agmatine Pathway for Putrescine Synthesis in Selenomonas ruminatium
- Occurrence of Agmatine Pathway for Putrescine Synthesis in Selenomonas ruminatium
- DNA Structure of Pectate Lyase I Gene Cloned from Erwinia carotovora(Microbiology & Fermentation Industry)
- Inhibition of DNA Synthesis by SN-07, a Novel Macromolecular Antibiotic(Biological Chemistry)
- Some Properties of a New Amphiphilic Compound Designated as Material M from Selenomonas ruminantium(Microbiology & Fermentation Industry)
- Neopeptins A and B, New Antifungal Antibiotics
- Inhibition of Microbial Cell Wall Synthesis by Lipopeptin A
- Beneficial Effects of FKS-508 (AF102B), a Selective M1 Agonist, on the Impaired Working Memory in AF64A-Treated Rats
- Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.
- Effects of intracerebroventricular injection of AF64A on learning behaviors in rats.
- Degradation of Organomercurials in Bacillus cereus
- Production of Molecular Hydrogen by Photosynthetic Bacteria with Raw Starch
- Some Properties of Pentachlorophenol-resistant Gram-negative Bacteria
- Degradation of D-Glutamic Acid in Bacterium