Microbial Polyhydroxylation of Progesterone by Acremonium strictum
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概要
- 論文の詳細を見る
Acremonium strictum NN106,which has been shown to have a unique hydroxylating ability on androstenedione, also transformed progesterone into a mixture of various products. Six products were isolated in sufficient amounts for structural analysis. Three products were found to have two hydroxy moieties on axial and equatorial positions at 7β, 15β-, 6β, 11α- and 11α, 15β-sites. The other three products had an extra 17α-hydroxyl on the above dihydroxy derivatives to give trihydroxy progesterone. This type of microbial polyhydroxylation of a steroid caused by a fungal strain has not been reported so far and 7β, 15β, 17α-trihydroxy-4-pregnene-3,20-dione is a hitherto unknown compound which was obtained for the first time in the course of this experiment. The 6β, 11α-dihydroxylation has been found in the transformation of androstenedione, but the other positions of hydroxyl introduction are different. The hydroxylating events caused by this strain were greatly influenced by the 17β side chain, especially by C20 keto moiety in the steroidal skeleton.
- 社団法人日本生物工学会の論文
- 1989-10-25
著者
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YOSHIHAMA Makoto
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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IIDA MITSUGI
Department of Applied Biological Science, Science University of Tokyo
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MIYATA Nobuo
Research Institute of Life Science
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NAKAKOSHI Masamichi
Research Institute of Life Science, Snow Brand Milk Products Co.Ltd.
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Iida M
Sci. Univ. Tokyo Noda Jpn
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Iida Mitsugi
Department Of Applied Biological Science Faculty Of Science And Technology Science Niversity Of Toky
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KAWANISHI Gosei
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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Kawanishi G
Snow Brand Milk Products Co. Ltd. Tochigi Jpn
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Kawanishi Gosei
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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TAMURA KEN-ICHI
Takara Shuzo Co. Ltd.
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TAMURA KOHJI
Research Institute of Life Science, Snow Brand Milk Products, Co. Ltd.,
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Iida M
Sci. Univ. Tokyo Chiba Jpn
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Yoshihama M
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd
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Yoshihama Makoto
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd
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Nakakoshi M
Snow Brand Milk Products Co. Ltd. Tochigi Jpn
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Nakakoshi Masamichi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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KAWANISHI GOSEI
Research lnstitute of Life Science, Snow Brand Milk Products, Co. Ltd.,
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