Microbial Hydroxylation of (-)-α-Santonin by Aspergillus niger : Studies on Microbial Transformations(XXIV)
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概要
- 論文の詳細を見る
The microbiological transformation of a sesquiterpene lactone, (-)-α-santonin was carried out by using Aspergillus niger MIL 5024 and MIL 5025. Strain MIL 5024 brings about the transformation of (-)-α-santonin (400 mg) to 11-hydroxy-(-)-α-santonin (P1) (50.4 mg), 3,6,9-trihydroxy-9,10-seco-selina-1,3,5(10)-trien-12-oci acid-12,6-lactone (P2) (22.4 mg), and 3,6-dihydroxy-9,10-seco-selina-1,3,5(10)-trien-9,12-dioic acid-12,6-lactone (P3) (27.1 mg), which were isolated and characterized by UV, IR, mass and ^1H-NMR spectroanalyses. All of these products are described for the first time. Results similar to those with MIL 5024 were also obtained from the trans formation of (-)-α-santonin by the other isolate, strain MIL 5025.
- 社団法人日本生物工学会の論文
- 1988-02-25
著者
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YAMAKAWA Koji
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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IIDA MITSUGI
Department of Applied Biological Science, Science University of Tokyo
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Iida M
Sci. Univ. Tokyo Noda Jpn
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Iida Mitsugi
Department Of Applied Biological Science Faculty Of Science And Technology Science Niversity Of Toky
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Yamakawa K
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Iida M
Sci. Univ. Tokyo Chiba Jpn
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Yamakawa K
Department Of Quantum Engineering Nagoya University
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NISHITANI KIYOSHI
Faculty of Pharmaceutical Science, Science University of Tokyo
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MIKAMI AKIKO
Department of Applied Biological Science, Science University of Tokyo
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Yamakawa Koji
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Mikami Akiko
Department Of Applied Biological Science Science University Of Tokyo
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Yamakawa Koji
Faculty Of Pharmaceutical Science Science University Of Tokyo
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Nishitani Kiyoshi
Faculty Of Pharmaceutical Science Science University Of Tokyo
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