Microbial Production of Two New Dihydroxylated Androstenedione Derivatives by Acremonium strictum
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概要
- 論文の詳細を見る
We found that Acremonium strictum NN106 converted 4-androstene-3,17-dione (androstenedione) to 12 compounds. Among them, five products were isolated and found to be hydroxylated at the 11a, 14a-, 7a, 11a-, 6β, 11a- or 6β, 14a-positions of androstenedione. 6β, 11a-Dihydroxy and 6β, 14a-dihydroxy derivatives of androstenedione have been obtained for the first time. From the time course profile of this transformation, sequential hydroxylation at the 6β-position followed by 11a- or 14a-monohydroxylation was observed. The oxidative product of the 6β, 14a-dihydroxy derivative was found to be the most potent inhibitor of human placentral aromatase.
- 社団法人日本生物工学会の論文
- 1989-04-25
著者
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YOSHIHAMA Makoto
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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IIDA MITSUGI
Department of Applied Biological Science, Science University of Tokyo
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MIYATA Nobuo
Research Institute of Life Science
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NAKAKOSHI Masamichi
Research Institute of Life Science, Snow Brand Milk Products Co.Ltd.
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Iida M
Sci. Univ. Tokyo Noda Jpn
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Iida Mitsugi
Department Of Applied Biological Science Faculty Of Science And Technology Science Niversity Of Toky
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KAWANISHI Gosei
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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Kawanishi G
Snow Brand Milk Products Co. Ltd. Tochigi Jpn
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Kawanishi Gosei
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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TAMURA KEN-ICHI
Takara Shuzo Co. Ltd.
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TAMURA KOHJI
Research Institute of Life Science, Snow Brand Milk Products, Co. Ltd.,
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Iida M
Sci. Univ. Tokyo Chiba Jpn
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Yoshihama M
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd
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Yoshihama Makoto
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd
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Nakakoshi M
Snow Brand Milk Products Co. Ltd. Tochigi Jpn
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Nakakoshi Masamichi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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KAWANISHI GOSEI
Research lnstitute of Life Science, Snow Brand Milk Products, Co. Ltd.,
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