Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.
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概要
- 論文の詳細を見る
Effect of AF102B (cis-2-methylspiro-(1, 3-oxathiolane-5, 3')-quinuclidine) on experimental amnesia was examined using a passive avoidance task in rodents. The amnesia was produced by anti-cholinergic agents, AF64A (intracerebroventricularly) and scopolamine (subcutaneously). AF102B ameliorated the memory deficits in AF64A-treated rats at 0.1-1 mg/kg, i.p. and at 1-5 mg/kg p.o. and in scopolamine-treated mice at 1-10 mg/kg, i.p. These results suggest that AF102B may compensate for central cholinergic defects and could be developed as a possible therapeutic drug for senile dementia of the Alzheimer type.
- 公益社団法人 日本薬理学会の論文
著者
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Kawanishi Gosei
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Iga Yoshinori
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Mizobe Fumio
Research Laboratories Taisho Pharmaceutical Co. Ltd.
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NAKAHARA Noboru
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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- Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.
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