Reconstruction of the Macromolecular Antitumor Antibiotic SN-07 from SN-07 Chromophore and DNA(Biological Chemistry)
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概要
- 論文の詳細を見る
To characterize the novel macromolecular antitumor antibiotic SN-07 and the role of DNA in SN-07, we reconstructed SN-07 in vitro from SN-07 chromophore and calf thymus DNA. Reconstructed SN-07 was identical with the native SN-07 in the ultraviolet absorption spectrum, nuclease-resistance characteristics, and biological activities (antibacterial activity and cytotoxicity). The DNA moiety promoted the cytotoxic activity of SN-07 chromophore against KB and HeLa cells, but suppressed the activity against some bacteria and L1210 cells. DNA containing guanine suppressed the activity more strongly than DNA not containing guanine against some bacteria and L1210 cells. The antibacterial activity of SN-07 chromophore was affected by dosage only when DNA was supplied, but not RNA or BSA. Thus the DNA composition of the SN-07 chromophore-DNA complex affected the activity of SN-07 chromophore and guanine had an important role of the binding of SN-07 chromophore to DNA.
- 社団法人日本農芸化学会の論文
- 1989-07-23
著者
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TAKAHASHI Hidetoshi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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KIMURA Ken-ichi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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NAKAYAMA SHOJI
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd
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MIYATA Nobuo
Research Institute of Life Science
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KAWANISHI Gosei
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
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Kawanishi Gosei
Research Institute Of Life Science Snow. Brand Milk Products Co. Ltd.
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Kawanishi Gosei
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Nakayama Shoji
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Nakayama Shoji
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd
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Nakayama Shoji
Department Of Public Health Okayama University Graduate School Of Medicine And Dentistry
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Kimura K
Research Institute Of Life Science
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Kimura K
Hokkaido Univ. Education Iwamizawa Jpn
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Takahashi H
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Takahashi Hidetoshi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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Kimura Ken-ichi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
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