Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae

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概要

• 論文の詳細を見る

• Fredericamycin A (FMA) is an antibiotic product of Streptomyces griseus that exhibits modest antitumor activity in vivo and in vitro, but, its functions in vivo are poorly understood. We identified this compound as an inducer of G1 arrest in the yeast, Saccharomyces cerevisiae. FMA exhibits an IC50 of 24 nM towards the growth of a disruptant of multi-drug resistance genes, W303-MLC30, and its cytotoxicity is a function of the time of exposure as well as drug dose. Addition of 0.8 μM of FMA caused aggregation of mitochondria within 10 min of incubation and the drug induced petites at high frequency after 4 h of incubation. rho− cells were about 20 times more resistant to FMA than isogenic rho+ cells. Overexpression of topoisomerase I, a previously suggested target of the drug, did not alleviate the sensitivity of the cells to FMA or the aggregation of mitochondria. Our results suggest that mitochondria are the primary target site of FMA.

• 社団法人 日本農芸化学会の論文
• 2005-11-23

著者

• Tsuchiya Eiko

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni

• Yukawa Masashi

  Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni

• KIMURA Ken-ichi

  Department of Biological Chemistry and Food Science, Iwate University

• TAKAHASHI Hidetoshi

  Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.

• Suzuki Y

  Exploratory Medicinal Sciences Pgrd Nagoya Laboratories Pfizer Pharmaceuticals Inc.

• IMAMURA Yuko

  Department of Dermatology, School of Medicine, Iwate Medical University

• Imamura Yuko

  Department Of Dermatology Iwate Medical University School Of Medicine

• Imamura Yuko

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Suzuki Yoshihiro

  Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine

• Suzuki Yoshihiro

  Graduate School Of Bioagricultural Sciences Nagoya University

• SAKAGAMI Youji

  Department of Biological Sciences, Nagoya University

• Sakagami Y

  Nagoya Univ. Nagoya Jpn

• Sakagami Youji

  Department Of Agricultural Chemistry Nagoya University

• Okada Masahiro

  Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.

• Suzuki Yumiko

  Exploratory Medicinal Sciences Pgrd Nagoya Laboratories Pfizer Pharmaceuticals Inc.

• Kimura Ken-ichi

  Lab. Of Chemical Biology The United Graduate School Of Agricultural Sciences Iwate Univ.

• OJIKA Makoto

  Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya Univ

• Okada Masahiro

  Dep. Of Chemistry Tohoku Univ.

• Kaida Ken-ichi

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Takahashi Hiroko

  Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.

• Ojika M

  Graduate School Of Bioagricultural Sciences Nagoya University

• Makoto Ojika

  Graduate School Of Bioagricultural Sciences Nagoya University

• Tsuchiya E

  Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.

• Tsuchiya Eiko

  Department Of Fermentation Technology Faculty Of Engineering Hiroshima University

• Tsuchiya Eiko

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Yukawa Masashi

  Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.

• Yukawa Masashi

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Tsuchiya E

  Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive

• Suzuki Yoshihiro

  Department Of Civil And Environmental Engineering Faculty Of Engineering University Of Miyazaki

• Takahashi Hidetoshi

  Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.

• Suzuki Yoshihiro

  Department Of Biological Science Graduate School Of Sciences Kanagawa University

• Suzuki Yoshihiro

  Department Of Advanced Materials Chemistry Faculty Of Engineering Yokohama National University

• Ojika Makoto

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya University

• Suzuki Yoshihiro

  Graduate School of Bioagricultural Sciences, Nagoya University

• KIMURA Ken-ichi

  Department of Agro-bioscience, Faculty of Agriculture, Iwate University

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