Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae
スポンサーリンク
概要
- 論文の詳細を見る
Fredericamycin A (FMA) is an antibiotic product of Streptomyces griseus that exhibits modest antitumor activity in vivo and in vitro, but, its functions in vivo are poorly understood. We identified this compound as an inducer of G1 arrest in the yeast, Saccharomyces cerevisiae. FMA exhibits an IC50 of 24 nM towards the growth of a disruptant of multi-drug resistance genes, W303-MLC30, and its cytotoxicity is a function of the time of exposure as well as drug dose. Addition of 0.8 μM of FMA caused aggregation of mitochondria within 10 min of incubation and the drug induced petites at high frequency after 4 h of incubation. rho− cells were about 20 times more resistant to FMA than isogenic rho+ cells. Overexpression of topoisomerase I, a previously suggested target of the drug, did not alleviate the sensitivity of the cells to FMA or the aggregation of mitochondria. Our results suggest that mitochondria are the primary target site of FMA.
- 社団法人 日本農芸化学会の論文
- 2005-11-23
著者
-
Tsuchiya Eiko
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
-
Yukawa Masashi
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
-
KIMURA Ken-ichi
Department of Biological Chemistry and Food Science, Iwate University
-
TAKAHASHI Hidetoshi
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.
-
Suzuki Y
Exploratory Medicinal Sciences Pgrd Nagoya Laboratories Pfizer Pharmaceuticals Inc.
-
IMAMURA Yuko
Department of Dermatology, School of Medicine, Iwate Medical University
-
Imamura Yuko
Department Of Dermatology Iwate Medical University School Of Medicine
-
Imamura Yuko
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
-
Suzuki Yoshihiro
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
-
Suzuki Yoshihiro
Graduate School Of Bioagricultural Sciences Nagoya University
-
SAKAGAMI Youji
Department of Biological Sciences, Nagoya University
-
Sakagami Y
Nagoya Univ. Nagoya Jpn
-
Sakagami Youji
Department Of Agricultural Chemistry Nagoya University
-
Okada Masahiro
Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.
-
Suzuki Yumiko
Exploratory Medicinal Sciences Pgrd Nagoya Laboratories Pfizer Pharmaceuticals Inc.
-
Kimura Ken-ichi
Lab. Of Chemical Biology The United Graduate School Of Agricultural Sciences Iwate Univ.
-
OJIKA Makoto
Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya Univ
-
Okada Masahiro
Dep. Of Chemistry Tohoku Univ.
-
Kaida Ken-ichi
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
-
Takahashi Hiroko
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
-
Ojika M
Graduate School Of Bioagricultural Sciences Nagoya University
-
Makoto Ojika
Graduate School Of Bioagricultural Sciences Nagoya University
-
Tsuchiya E
Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.
-
Tsuchiya Eiko
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
-
Tsuchiya Eiko
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
-
Yukawa Masashi
Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.
-
Yukawa Masashi
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
-
Tsuchiya E
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
-
Suzuki Yoshihiro
Department Of Civil And Environmental Engineering Faculty Of Engineering University Of Miyazaki
-
Takahashi Hidetoshi
Research Institute Of Life Science Snow Brand Milk Products Co. Ltd.
-
Suzuki Yoshihiro
Department Of Biological Science Graduate School Of Sciences Kanagawa University
-
Suzuki Yoshihiro
Department Of Advanced Materials Chemistry Faculty Of Engineering Yokohama National University
-
Ojika Makoto
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya University
-
Suzuki Yoshihiro
Graduate School of Bioagricultural Sciences, Nagoya University
-
KIMURA Ken-ichi
Department of Agro-bioscience, Faculty of Agriculture, Iwate University
関連論文
- A Novel Method of Screening Cell-Cycle Blockers as Candidates for Anti-Tumor Reagents Using Yeast as a Screening Tool
- Trichoblastoma with Rippled-Pattern
- Longitudinal Analysis of Cytokines and Chemokines in the Cerebrospinal Fluid of a Patient with Neuro-Sweet Disease Presenting with Recurrent Encephalomeningitis
- Promotive Effects of the Peptidyl Plant Growth Factor, Phytosulfokine-α, on the Growth and Chlorophyll Content of Arabidopsis Seedlings under High Night-time Temperature Conditions
- Promotion by a Peptidyl Growth Factor, Phytosulfokine, of Chlorophyll Formation in Etiolated Cotyledon of Cucumber
- New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces
- New Types of Liposidomycins that Inhibit Bacterial Peptdoglycan Synthesis and are Produced by Streptomyces I. Producing Organism and Medium Components
- Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
- Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
- P-146 NOVEL POSTTRANSLATIONAL MODIFICATION : GERANYL MODIFICATION ON TRYPTOPHAN RESIDUE RESULTING FORMATION OF TRICYCLIC RING STRUCTURE
- Towards Structural Determination of the ComX Pheromone : Synthetic Studies on Peptides Containing Geranyltryptophan
- Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora I. Fermentation, Isolation and Biological Properties
- New Piericidin Antibiotics, 7-Demethylpiericidin A_1 and 7-Demethyl-3'-rhamnopiericidin A_1
- Short Communication Synthesis and Structure-Activity Relations of Tremerogen a-13, a Peptidal Sex Hormone of Tremella mesenterica
- A basic analysis on the structure of the service system living in community for intellectual disabled persons
- Short-Range Structure of Vitreous P_2O_5 by MD Simulation
- Stromal cell activity in bone marrow from the tibia and iliac crest of patients with rheumatoid arthritis
- Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae
- Construction of a Bacterial Artificial Chromosome Library for a Myxobacterium of the Genus Cystobacter and Characterization of an Antibiotic Biosynthetic Gene Cluster
- Biotransformation of Cystothiazole A, a Myxobacterial Antibiotic, into Novel Derivatives by the Mother Producer, Cystobacter fuscus
- Biosynthetic Studies on a Myxobacterial Antibiotic, Cystothaiazole A: Biosynthetic Precursors of the Carbon Skeleton
- New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 2. Structure Analysis
- New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 1. Taxonomy, Fermentation, Isolation, and Biological Properties
- Cystothiazoles A and B, New Bithiazole-type Antibiotics from the Myxobacterium Cystobacter fuscus
- Structural Studies and Antifungal Activity of Unique Polyene Amides, Clathrynamide A and Three New Derivatives, from a Marine Sponge, Psammoclemma Sp.(Organic Chemistry)
- CJ-21,058, a New SecA Inhibitor Isolated from a Fungus
- CJ-15,801, a Novel Antibiotic from a Fungus, Seimatosporium sp.
- New Pyrrolizidinone Antibiotics CJ-16,264 and CJ-16,367
- A Novel Antibiotic CJ-17,572 from a Fungus, Pezicula sp.
- A New Antibiotic CJ-17,665 from Aspergillus ochraceus
- Pigmented Epidermal Cyst
- CJ-15,696 and Its Analogs, New Furopyridine Antibiotics from the Fungus Cladobotryum varium : Fermentation, Isolation, Structural Elucidation, Biotransformation and Antibacterial Activities
- Cytokine Production Inhibitors Produced by a Fungus, Oidiodendron griseum
- Novel Cytokine Production Inhibitors Produced by a Basidiomycete, Marasmiellus sp.
- New Quinolone Compounds from Pseudonocardia sp. with Selective and Potent Anti-Helicobacter pylori Activity: Taxonomy of Producing Strain, Fermentation, Isolation, Structural Elucidation and Biological Activities
- CJ-12, 373, a Novel Topoisomerase II Inhibitor: Fermentation, Isolaton, Atructure Elucidation and Biological Activities
- Novel Lactone Compounds from Mortierella verticillata that Induce the Human Low Density Lipoprotein Receptor Gene: Fermentation, Isolation, Structural Elucidation and Biological Activities
- CJ-12, 954 and Its Congeners, New Abti-Helicobacter pylori Compounds Produced by Phanerochaete velutina: Fermentation, Isolation, Structural Elucidation and Biological Activities
- Erinacine E as a Kappa Opioid Receptor Agonist and Its New Analogs from a Basidiomycete, Hericium ramosum
- CJ-15,183, a New Inhibitor of Squalene Synthase Produced by a Fungus, Aspergillus aculeatus
- Biological Activities of Anthracycline Antibiotic SN-07 Chromophore and SN-07 Chromophore-DNA Complexes(Biological Chemistry)
- Reconstruction of the Macromolecular Antitumor Antibiotic SN-07 from SN-07 Chromophore and DNA(Biological Chemistry)
- Borrelidin Inhibits a Cyclin-dependent Kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae
- Raw Materials for Low-Activation Concrete Neutron Shields
- Correlation between Tritium and ^Eu Induced in Various Types of Concrete by Thermal Neutron Irradiation
- A Rapid and Efficient System of Agrobacterium Infection-Mediated Transient Gene Expression in Rice Oc Cells and Its Application for Analysis of the Expression and Antisense Suppression of Preprophytosulfokine, a Precursor of Phytosulfokine-α, Encoded by O
- Preparation and Characterization of Fully Active Biotinylated Analogs of Phytosulfokine-α
- Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase
- Differential Effects of Protein Tyrosine Kinase Inhibitors on Interferon-γ-Induction of Major Histocompatibility Complex Class II and Intercellular Adhesion Molecule-1 Expression in Human Corneal Epitnelial Cells
- ALLOPURINOL TOXICITY : ITS TOXIC ORGAN-SPECIFICITY BETWEEN THE LIVER AND THE KIDNEY IN THE RAT
- Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium : Taxonomy, Production, and Biological Properties
- Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.(Organic Chemistry)
- Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
- Is bone density in the distal femur affected by use of cement and by femoral component design in total knee arthroplasty?
- P-494 Polymer-Assisted Solution-phase Synthesis of 15-Deoxy-Δ^-PGJ_2 Derivatives and their Neurite Outgrowth-Promoting Activity
- Prostaglandins from a Zoanthid : Paclitaxel-Like Neurite-Degenerating and Microtubule-Stabilizating Activities
- 16(I-2) Novel Saponins from the Okinawan Starfish Linckia laevigata : Structure Determination, Neuritogenic Activity, and Mechanism of Action
- A Functional Analysis of the Yeast Ubiquitin Ligase Rsp5: The Involvement of the Ubiquitin-Conjugating Enzyme Ubc4 and Poly-Ubiquitination in Ethanol-Induced Down-Regulation of Targeted Proteins
- Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery:Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling
- Early-phase Neutrophilia in Cigarette Smoke-induced Acute Eosinophilic Pneumonia
- Zooxanthellactone, a Novel γ-Lactone-type Oxylipine from Dinoflagellates of Symbiodinium sp : Structure, Distribution, and Biological Activity
- New Haliangicin Isomers, Potent Antifungal Metabolites Produced by a Marine Myxobacterium
- P-145 CHARACTERIZATION OF A PHYTOPHTHORA MATING HORMONE
- Biosynthesis of 2'-O-Methylmyxalamide D in the Myxobacterium Cystobacter fuscus : a Polyketide Synthase-Nonribosomal Peptide Synthetase System for the Myxalamide D Skeleton and a Methyltransferase for the Final O-Methylation
- Differentiation in a Rat PC12 Cell Line Induced by Ostruthin and (-)-Bornyl Ferulate, Constitutents of a Chinese Herbal Medicine
- The Promotive Effects of a Peptidyl Plant Growth Factor, Phytosulfokine-α, on the Formation of Adventitious Roots and Expression of a Gene for a Root-Specific Cystatin in Cucumber Hypocotyls
- Biosynthesis of Phytosulfokine, Plant Cell Growth Factor
- Phytosulfokine-α, a Peptide Growth Factor Found in Higher Plants:Its Structure, Functions, Precursor and Receptors
- SPINOCEREBELLAR ATAXIA 1 (SCA1) IN THE JAPANESE : ANALYSIS OF CAG TRINUCLEITIDE REPEAT EXPANSION AND INSTABILITY OF THE REPEAT FOR PATERNAL TRANSMISSION
- Characteristic Decrease of Nuclear Protein Kinase Activity in Gl-Arrested Cells of Saccharo-myces cerevisiae cdc28
- Development of a physiological knee motion simulator
- Highly Stereoselective Synthesis of (E)-Substituted Allylsilanes via the Still-Wittig Rearrangement
- Isolation and Structure of the Streptococcus faecalis Sex Pheromone Inhibitor, iAD1, That Is Excreted by the Donor Strain Harboring Plasmid pAD1
- Structure of Tremerogen a-13, a Peptidal Sex Hormone of Tremella mesenterica
- Isolation of Tremerogen a-13, a Peptidal Sex Hormone of Tremella mesenterica
- Inhibition of Ca^-Signal-Dependent Growth Regulation by Radicicol in Budding Yeast
- A Positive Screening for Drugs that Specifically Inhibit the Ca^-Signaling Activity on the Basis of the Growth Promoting Effect on a Yeast Mutant with a Peculiar Phenotype
- Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
- Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
- Screening of Drugs That Suppress Ste11 MAPKKK Activation in Yeast Identified a c-Abl Tyrosine Kinase Inhibitor
- Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase
- The Rpd3/HDAC Complex Is Present at the URS1 cis-Element with Hyperacetylated Histone H3
- The Physiological Roles of Membrane Ergosterol as Revealed by the Phenotypes of syr1/erg3 Null Mutant of Saccharomyces cerevisiae
- Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
- A Novel Method of Screening Cell-Cycle Blockers as Candidates for Anti-Tumor Reagents Using Yeast as a Screening Tool
- Expression of Mutant RPA in Human Cancer Cells Causes Telomere Shortening
- The Bisabolane Sesquiterpenoid Endoperoxide, 3, 6-Epidioxy-1, 10-bisaboladiene, Isolated from Cacalia delphiniifolia Inhibits the Growth of Human Cancer Cells and Induces Apoptosis
- RSC Nucleosome-remodeling Complex Plays Prominent Roles in Transcriptional Regulation throughout Budding Yeast Gametogenesis
- THE PARTIAL AGONIST ACTIVITY OF XAMOTEROL (ICI 118,587) STUDIED BY HEART RATE RESPONSE IN PITHED RATS
- Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes
- Effect of etidronate on COX-2 expression and PGE_2 production in macrophage-like RAW 264.7 cells stimulated by titanium particles
- PA134 4-CHLOROTRYPTOPHAN. SYNTHESIS, RESOLUTION AND DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY, AND ITS IDENTIFICATION IN THE CRUDE SEED PROTEIN OF PEA, PISUM SATIVUM
- New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
- Visualization of the Articulation of Replaced Knee Joint Surfaces After Total Knee Arthroplasty
- Pathophysiological Response to Hypoxia-From the Molecular Mechanisms of Malady to Drug Discovery : Inflammatory Responses of Hypoxia-Inducible Factor 1α (HIF-1α) in T Cells Observed in Development of Vascular Remodeling
- PA104 β-GLUCAN SYNTHESIS-INHIBITORS FROM FUNGAL METABOLITES
- Reassignment of the Absolute Stereochemistry of N-Malonyl-tryptophan in Higher Plants
- Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus
- Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
- Gizzerosine, a New Toxic Substance in Fish Meal, Causes Severe Gizzard Erosion in Chicks