Zooxanthellactone, a Novel γ-Lactone-type Oxylipine from Dinoflagellates of Symbiodinium sp : Structure, Distribution, and Biological Activity

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概要

• 論文の詳細を見る

• A novel fatty acid derivative named zooxanthellactone (ZL) was isolated from several strains of symbiotic microalgae, dinoflagellates of the genus Symbiodinium. The metabolite is structurally related to docosahexaenoic acid (DHA) and seems to be biosynthesized by oxidation and subsequent lactonization. The absolute stereochemistry was determined from the specific rotation of the perhydro derivative. The distribution of ZL within several Symbiodinium isolates was quantitatively analyzed by HPLC techniques and suggested a relationship between the productivity of this metabolite and the Symbiodinium phylogeny. The cytotoxicity of ZL was evaluated by using human squamous cell carcinoma cell lines in comparison with that of DHA and other common fatty acids, suggesting that the long unsaturated chain was important rather than the γ-lactone moiety.

• 社団法人 日本農芸化学会の論文
• 2004-04-23

著者

• Okada Masahiro

  Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.

• OJIKA Makoto

  Graduate School of Bioagricultural Sciences, Nagoya University

• Onodera Ken-ichi

  Graduate School Of Bioagricultural Sciences Nagoya University

• Okada Masahiro

  Dep. Of Chemistry Tohoku Univ.

• Okamoto Tetsuji

  Graduate School Of Biomedical Sciences Hiroshima Univ.

• Onodera K

  Graduate School Of Bioagricultural Sciences Nagoya University

• Ojika M

  Graduate School Of Bioagricultural Sciences Nagoya University

• Makoto Ojika

  Graduate School Of Bioagricultural Sciences Nagoya University

• Okamoto T

  Graduate School Of Biomedical Sciences Hiroshima University

• FUKATSU Takuya

  Graduate School of Bioagricultural Sciences, Nagoya University

• KAWAI Nozomi

  Graduate School of Bioagricultural Sciences, Nagoya University

• YOSHIOKA Yukio

  Graduate School of Biomedical Sciences, Hiroshima University

• NAKAMURA Hideshi

  Graduate School of Bioagricultural Sciences, Nagoya University

• Okamoto T

  Graduate School Of Biomedical Sciences Hiroshima Univ.

• Yoshioka Yukio

  Graduate School Of Biomedical Sciences Hiroshima Univ.

• Nakamura Hideshi

  Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Ojika Makoto

  Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Nakamura Hideshi

  Graduate School Of Bioagricultural Sciences Nagoya University

• Kawai Nozomi

  Graduate School Of Bioagricultural Sciences Nagoya University

• Fukatsu Takuya

  Graduate School Of Bioagricultural Sciences Nagoya University

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