Biosynthesis of 2'-O-Methylmyxalamide D in the Myxobacterium Cystobacter fuscus : a Polyketide Synthase-Nonribosomal Peptide Synthetase System for the Myxalamide D Skeleton and a Methyltransferase for the Final O-Methylation

スポンサーリンク

概要

• 論文の詳細を見る

• The biosynthetic gene cluster for the polyene antifungal antibiotic, 2′-O-methylmyxalamide D, was cloned from myxobacterium Cystobacter fuscus AJ-13278. A sequence analysis of the 12.8-kb region in the gene cluster revealed the presence of two type I polyketide synthase genes, mmxB and mmxC. The involvement of these two genes in the biosynthesis of 2′-O-methylmyxalamide D was confirmed by a gene disruption experiments. In addition, an S-adenosylmethionine-dependent methyltransferase gene (mmxM) was found downstream of the gene cluster and demonstrated, by a gene disruption analysis, to be responsible for converting the known unmethylated precursor, myxalamide D, into 2′-O-methylmyxalamide D.

• 社団法人 日本農芸化学会の論文
• 2006-03-23

著者

• Suzuki Yoshihiro

  Graduate School Of Bioagricultural Sciences Nagoya University

• Sakagami Y

  Nagoya Univ. Nagoya Jpn

• Sakagami Youji

  Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Sakagami Youji

  Graduate School Of Bio-agricultural Sciences Nagoya University

• Okada Masahiro

  Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.

• QI Jianhua

  Graduate School of Bioagricultural Sciences, Nagoya University

• OJIKA Makoto

  Graduate School of Bioagricultural Sciences, Nagoya University

• Qi Jianhua

  Graduate School Of Bioagricultural Sciences Nagoya University

• FENG Zhiyang

  Graduate School of Bioagricultural Sciences, Nagoya University

• TSUGE Takashi

  Graduate School of Bioagricultural Sciences, Nagoya University

• OBA Yuichi

  Graduate School of Bioagricultural Sciences, Nagoya University

• Okada Masahiro

  Dep. Of Chemistry Tohoku Univ.

• Oba Yuichi

  Graduate School Of Bioagricultural Sciences Nagoya University

• Oba Yuichi

  Graduate School Of Bioagricultural Sciences

• Feng Zhiyang

  Graduate School Of Bioagricultural Sciences Nagoya University

• Ojika M

  Graduate School Of Bioagricultural Sciences Nagoya University

• Makoto Ojika

  Graduate School Of Bioagricultural Sciences Nagoya University

• Tsuge Takashi

  Graduate School Of Bioagricultural Sciences Nagoya University

• Ojika Makoto

  Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Qi Jianhua

  Coll. Of Pharmaceutical Sciences Zhejiang Univ.

• Qi Jianhua

  College Of Pharmaceutical Sciences Zhejiang University

• Oba Yuichi

  Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Suzuki Yoshihiro

  Graduate School of Bioagricultural Sciences, Nagoya University

• Qi Jianhua

  College of Pharmaceutical Sciences, Zhejiang University

関連論文

• Stereoselective Incorporation of Isoleucine into Cypridina Luciferin in Cypridina hilgendorfii (Vargula hilgendorfii)
• Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
• Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
• P-146 NOVEL POSTTRANSLATIONAL MODIFICATION : GERANYL MODIFICATION ON TRYPTOPHAN RESIDUE RESULTING FORMATION OF TRICYCLIC RING STRUCTURE
• Towards Structural Determination of the ComX Pheromone : Synthetic Studies on Peptides Containing Geranyltryptophan
• Short-Range Structure of Vitreous P_2O_5 by MD Simulation
• Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae
• Construction of a Bacterial Artificial Chromosome Library for a Myxobacterium of the Genus Cystobacter and Characterization of an Antibiotic Biosynthetic Gene Cluster
• Biotransformation of Cystothiazole A, a Myxobacterial Antibiotic, into Novel Derivatives by the Mother Producer, Cystobacter fuscus
• Biosynthetic Studies on a Myxobacterial Antibiotic, Cystothaiazole A: Biosynthetic Precursors of the Carbon Skeleton
• New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 2. Structure Analysis
• New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 1. Taxonomy, Fermentation, Isolation, and Biological Properties
• Cystothiazoles A and B, New Bithiazole-type Antibiotics from the Myxobacterium Cystobacter fuscus
• Structural Studies and Antifungal Activity of Unique Polyene Amides, Clathrynamide A and Three New Derivatives, from a Marine Sponge, Psammoclemma Sp.(Organic Chemistry)
• P-2 STUDY OF THE LETHAL VENOM FROM THE SHORT-TAILED SHREW Blarina brevicauda
• Purification and characterisation of blarinasin, a new tissue kallikrein-like protease from the short-tailed shrew Blarina brevicauda: comparative studies with blarina toxin
• Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda : Isolation and characterization
• Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative
• Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
• A Rapid and Efficient System of Agrobacterium Infection-Mediated Transient Gene Expression in Rice Oc Cells and Its Application for Analysis of the Expression and Antisense Suppression of Preprophytosulfokine, a Precursor of Phytosulfokine-α, Encoded by O
• Preparation and Characterization of Fully Active Biotinylated Analogs of Phytosulfokine-α
• Determination of the Luciferin Contents in Luminous and Non-Luminous Beetles
• Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium : Taxonomy, Production, and Biological Properties
• P-578 CHARACTERIZATION OF PARALYTIC SUBSTANCE FROM THE VENOM OF SPIDER WASP : Cyphononyx dorsalis
• Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.(Organic Chemistry)
• Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
• P-494 Polymer-Assisted Solution-phase Synthesis of 15-Deoxy-Δ^-PGJ_2 Derivatives and their Neurite Outgrowth-Promoting Activity
• Prostaglandins from a Zoanthid : Paclitaxel-Like Neurite-Degenerating and Microtubule-Stabilizating Activities
• 16(I-2) Novel Saponins from the Okinawan Starfish Linckia laevigata : Structure Determination, Neuritogenic Activity, and Mechanism of Action
• Structural analysis of cosmid clone pcAFT-2 carrying AFT10-1 encoding an acyl-CoA dehydrogenase involved in AF-toxin production in the strawberry pathotype of Alternaria alternata
• A Functional Analysis of the Yeast Ubiquitin Ligase Rsp5: The Involvement of the Ubiquitin-Conjugating Enzyme Ubc4 and Poly-Ubiquitination in Ethanol-Induced Down-Regulation of Targeted Proteins
• Zooxanthellactone, a Novel γ-Lactone-type Oxylipine from Dinoflagellates of Symbiodinium sp : Structure, Distribution, and Biological Activity
• New Haliangicin Isomers, Potent Antifungal Metabolites Produced by a Marine Myxobacterium
• Linckosides M-Q : neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
• P-207 Linckosides, novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
• P-145 CHARACTERIZATION OF A PHYTOPHTHORA MATING HORMONE
• Biosynthesis of 2'-O-Methylmyxalamide D in the Myxobacterium Cystobacter fuscus : a Polyketide Synthase-Nonribosomal Peptide Synthetase System for the Myxalamide D Skeleton and a Methyltransferase for the Final O-Methylation
• Novel Relationship between the Antifungal Activity and Cytotoxicity of Marine-Derived Metabolite Xestoquinone and Its Family
• Differentiation in a Rat PC12 Cell Line Induced by Ostruthin and (-)-Bornyl Ferulate, Constitutents of a Chinese Herbal Medicine
• Stomatal Density is Controlled by a Mesophyll-Derived Signaling Molecule
• Biosynthesis of Phytosulfokine, Plant Cell Growth Factor
• Phytosulfokine-α, a Peptide Growth Factor Found in Higher Plants:Its Structure, Functions, Precursor and Receptors
• Reporter Gene Analysis of AKT3-1 and AKT3-2 Expression During Conidial Germination of the Japanese Pear Pathotype of Alternaria alternata
• Highly Stereoselective Synthesis of (E)-Substituted Allylsilanes via the Still-Wittig Rearrangement
• Enzymatic and Genetic Characterization of Firefly Luciferase and Drosophila CG6178 as a Fatty Acyl-CoA Synthetase
• A Functional Analysis of the Yeast Ubiquitin Ligase Rsp5 : The Involvement of the Ubiquitin-Conjugating Enzyme Ubc4 and Poly-Ubiquitination in Ethanol-Induced Down-Regulation of Targeted Proteins
• Zooxanthellamide B, a Novel Large Polyhydroxy Metabolite from a Marine Dinoflagellate of Symbiodinium sp
• Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
• Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
• Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
• Phytosulfokine Stimulates Somatic Embryogenesis in Cryptomeria japonica
• Isolation of Pathogenicity Mutants of Fusarium oxysporum f.sp.melonis by Insertional Mutagenesis
• Occurrence of Fusarium oxysporum f.sp.melonis Race 1 in Japan
• DNA transposon fossils present on the conditionally dispensable chromosome controlling AF-toxin biosynthesis and pathogenicity of Alternaria alternata
• Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes
• Determination of the Luciferin Contents in Luminous and Non-Luminous Beetles
• Catalytic Properties of Domain-Exchanged Chimeric Proteins between Firefly Luciferase and Drosophila Fatty Acyl-CoA Synthetase CG6178
• Aplysiallene, a New Bromoallene as an Na, K-ATPase Inhibitor from the Sea Hare, Aplysia kurodai
• Occurrence of blood disease of banana in Sumatra, Indonesia
• Biosynthesis of cypridina luciferin in Cypridina noctiluca
• Identification of genes with changes in transcription levels caused by mutations in conidiation regulator genes REN1 and FoSTUA in Fusarium oxysporum
• Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum
• Generation of Polyclonal Antibody against Peptide Toxin μ-Conotoxin GIIIA
• Modification to Arg-13 of μ-Conotoxin GIIIA with Piperidinyl-Arg Analogs and Their Evaluations
• New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
• New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
• Visualization of the Articulation of Replaced Knee Joint Surfaces After Total Knee Arthroplasty
• Chromosome constitution of hybrid strains constructed by protoplast fusion between the tomato and strawberry pathotypes of Alternaria alternata
• Identification of putative defense-related genes in Japanese pear against Alternaria alternata infection using suppression subtractive hybridization and expression analysis
• Multiple copies of AMT2 are prerequisite for the apple pathotype of Alternaria alternata to produce enough AM-toxin for expressing pathogenicity
• Analogs of the CLV3 Peptide : Synthesis and Structure-Activity Relationships Focused on Proline Residues
• Studies on pathogenicity genes of Alternaria alternata
• Functional analysis of the melanin biosynthesis genes ALM1 and BRM2-1 in the tomato pathotype of Alternaria alternata
• Novel Cytotoxic Polyoxygenated Steroids from an Okinawan Sponge Dysidea sp.
• Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus
• Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
• Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
• Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus
• Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor
• Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus

もっと見る 閉じる

スポンサーリンク