New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl

スポンサーリンク

概要

• 論文の詳細を見る

• A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4′ of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.

• 社団法人 日本農芸化学会の論文

著者

• WANG Yan

  College of Animal Science and Technology, Sichuan Agricultural University

• 張 雁

  広島大学大学院 医歯薬学総合研究科 創生医科学専攻 先進医療開発科学講座 分子口腔医学・顎顔面外科学

• Sakagami Youji

  Graduate School Of Bio-agricultural Sciences Nagoya University

• Ojika Makoto

  Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Qi Jianhua

  College Of Pharmaceutical Sciences Zhejiang University

• ZHANG Yang

  College of Biology and Science, Sichuan Agricultural University

• Huang Qianming

  College Of Biology And Science Sichuan Agricultural University

• QU Yuan

  College of Pharmaceutical Sciences, Zhejiang University

• PEI Liang

  College of Biology and Science, Sichuan Agricultural University

• GAO Lijuan

  College of Pharmaceutical Sciences, Zhejiang University

• Qu Yuan

  College Of Pharmaceutical Sciences Zhejiang University

• Pei Liang

  College Of Biology And Science Sichuan Agricultural University

関連論文

• Study on Association of Single Nucleotide Polymorphism of MC3R and MC4R Genes with Carcass and Meat Quality Traits in Chicken
• 軟サンゴ由来抗腫瘍活性物質の精製とその作用機構
• エナメル上皮癌における新規可溶化性FGFR3受容体の同定
• 口腔扁平上皮癌細胞における MHC class 1 chain-related molecule A(MICA) および分泌型MICAの発現と TGF-beta による制御
• Developmental Signaling Disorders in Craniofacial Anomalies and Cancers
• 口腔粘膜上皮細胞および口腔扁平上皮癌細胞株における Patched-1 Splicing Variant の同定とその機能解析
• 正常ヒト唾液腺におけるアンジオポイエチン2とその受容体Tie2の機能解析
• ラット唾液腺由来幹細胞の増殖・分化におけるアクチビンAの作用
• Epidermal Growth Factor Receptor を標的とした扁平上皮癌の分子標的治療に関する研究
• 血管新生における Endothelial-specific Receptor Tyrosine Kinase Tie-2 遺伝子の機能
• 口腔扁平上皮癌細胞のマトリックスメタロプロプロテアーゼ2(MMP-2)活性化機構における線維芽細胞の関与
• ヘパリン親和性FGF結合蛋白HBp17の扁平上皮癌細胞における機能解析
• 野生型KGF受容体遺伝子導入による唾液腺由来腺癌細胞のアポトーシス誘導
• 頭蓋骨早期癒合症および軟骨無形成症の遺伝子診断
• ヒト歯周靭帯由来上皮細胞の細胞内分泌学的研究
• Wild-type KGFR 遺伝子移入によるヒト唾液腺由来腺癌細胞の増殖制御
• ヘパリン結合性FGF結合蛋白HBp17の正常および腫瘍細胞における発現とその機能解析
• Stereoselective Incorporation of Isoleucine into Cypridina Luciferin in Cypridina hilgendorfii (Vargula hilgendorfii)
• P-146 NOVEL POSTTRANSLATIONAL MODIFICATION : GERANYL MODIFICATION ON TRYPTOPHAN RESIDUE RESULTING FORMATION OF TRICYCLIC RING STRUCTURE
• Towards Structural Determination of the ComX Pheromone : Synthetic Studies on Peptides Containing Geranyltryptophan
• Construction of a Bacterial Artificial Chromosome Library for a Myxobacterium of the Genus Cystobacter and Characterization of an Antibiotic Biosynthetic Gene Cluster
• Biotransformation of Cystothiazole A, a Myxobacterial Antibiotic, into Novel Derivatives by the Mother Producer, Cystobacter fuscus
• Biosynthetic Studies on a Myxobacterial Antibiotic, Cystothaiazole A: Biosynthetic Precursors of the Carbon Skeleton
• New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 2. Structure Analysis
• New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 1. Taxonomy, Fermentation, Isolation, and Biological Properties
• Cystothiazoles A and B, New Bithiazole-type Antibiotics from the Myxobacterium Cystobacter fuscus
• Structural Studies and Antifungal Activity of Unique Polyene Amides, Clathrynamide A and Three New Derivatives, from a Marine Sponge, Psammoclemma Sp.(Organic Chemistry)
• Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative
• Effects of the pericarp on imbibition, seed germination, and seedling establishment in seeds of Hedysarum scoparium Fisch. et Mey
• アクチビンAによる唾液腺導管由来RSMG-1上皮細胞における腺房細胞マーカーSel-11遺伝子の発現誘導
• Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
• Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium : Taxonomy, Production, and Biological Properties
• Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.(Organic Chemistry)
• Prostaglandins from a Zoanthid : Paclitaxel-Like Neurite-Degenerating and Microtubule-Stabilizating Activities
• 16(I-2) Novel Saponins from the Okinawan Starfish Linckia laevigata : Structure Determination, Neuritogenic Activity, and Mechanism of Action
• Zooxanthellactone, a Novel γ-Lactone-type Oxylipine from Dinoflagellates of Symbiodinium sp : Structure, Distribution, and Biological Activity
• New Haliangicin Isomers, Potent Antifungal Metabolites Produced by a Marine Myxobacterium
• Linckosides M-Q : neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
• P-207 Linckosides, novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
• P-145 CHARACTERIZATION OF A PHYTOPHTHORA MATING HORMONE
• Biosynthesis of 2'-O-Methylmyxalamide D in the Myxobacterium Cystobacter fuscus : a Polyketide Synthase-Nonribosomal Peptide Synthetase System for the Myxalamide D Skeleton and a Methyltransferase for the Final O-Methylation
• Novel Relationship between the Antifungal Activity and Cytotoxicity of Marine-Derived Metabolite Xestoquinone and Its Family
• Differentiation in a Rat PC12 Cell Line Induced by Ostruthin and (-)-Bornyl Ferulate, Constitutents of a Chinese Herbal Medicine
• Stomatal Density is Controlled by a Mesophyll-Derived Signaling Molecule
• Biosynthesis of Phytosulfokine, Plant Cell Growth Factor
• Enzymatic and Genetic Characterization of Firefly Luciferase and Drosophila CG6178 as a Fatty Acyl-CoA Synthetase
• Zooxanthellamide B, a Novel Large Polyhydroxy Metabolite from a Marine Dinoflagellate of Symbiodinium sp
• Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
• Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
• Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
• Phytosulfokine Stimulates Somatic Embryogenesis in Cryptomeria japonica
• Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes
• Determination of the Luciferin Contents in Luminous and Non-Luminous Beetles
• Aplysiallene, a New Bromoallene as an Na, K-ATPase Inhibitor from the Sea Hare, Aplysia kurodai
• Rapid and simultaneous determination of hair polyamines as N-heptafluorobutyryl derivatives by gas chromatography-mass spectrometry
• Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum
• New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
• New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
• Synthesis of Zr-containing SBA-15 with Hollow Spherical Morphology
• Analogs of the CLV3 Peptide : Synthesis and Structure-Activity Relationships Focused on Proline Residues
• Novel Cytotoxic Polyoxygenated Steroids from an Okinawan Sponge Dysidea sp.
• Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus
• Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
• Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
• Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus
• Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor
• Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus

もっと見る 閉じる

スポンサーリンク