Novel Relationship between the Antifungal Activity and Cytotoxicity of Marine-Derived Metabolite Xestoquinone and Its Family
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概要
- 論文の詳細を見る
Xestoquinone and related metabolites (the xestoquinone family) occur in marine sponges and are known to show a variety of biological activities. In this study, the first comprehensive evaluation of antifungal activity was performed for xestoquinone and nine natural and unnatural analogues in comparison with their cytotoxicity. The cytotoxicity against two human squamous cell carcinoma cell lines, A431 and Nakata, indicated that the terminal quinone structure of the polycyclic molecules was important (xestoquinone, etc.) and that the presence of a ketone group at C-3 of the opposite terminus dramatically diminished the activity (halenaquinone, etc.). In contrast, a ketone group at C-3 enhanced the antifungal activity against the plant pathogen, Phytophthora capsici, regardless of the presence of a quinone moiety. The cytotoxicity and antifungal activity of the xestoquinone family were negatively correlated with each other.
- 社団法人 日本農芸化学会の論文
著者
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QI Jianhua
Graduate School of Bioagricultural Sciences, Nagoya University
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OJIKA Makoto
Graduate School of Bioagricultural Sciences, Nagoya University
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Qi Jianhua
Graduate School Of Bioagricultural Sciences Nagoya University
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OBA Yuichi
Graduate School of Bioagricultural Sciences, Nagoya University
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Okamoto Tetsuji
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Oba Yuichi
Graduate School Of Bioagricultural Sciences
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SHINTANI Tomoaki
Graduate School of Biomedical Sciences, Hiroshima University
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YOSHIOKA Yukio
Graduate School of Biomedical Sciences, Hiroshima University
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NAKAMURA Hideshi
Graduate School of Bioagricultural Sciences, Nagoya University
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Shintani Tomoaki
Graduate School Of Biomedical Sciences Hiroshima Univ.
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NAKAMURA Mitsuhiro
Graduate School of Bioagricultural Sciences, Nagoya University
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KAKUDA Takahiko
Graduate School of Bioagricultural Sciences, Nagoya University
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HIRATA Masayuki
Graduate School of Bioagricultural Sciences, Nagoya University
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Yoshioka Yukio
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Nakamura Hideshi
Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Ojika Makoto
Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Qi Jianhua
Coll. Of Pharmaceutical Sciences Zhejiang Univ.
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Qi Jianhua
College Of Pharmaceutical Sciences Zhejiang University
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Nakamura Mitsuhiro
Graduate Course Of Mechanical Engineering Graduate School Of Kogakuin University
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OKAMOTO Tetsuji
Graduate School of Biomedical Sciences, Hiroshima University
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