Anti-Aging Effects of Hesperidin on <I>Saccharomyces cerevisiae</I> <I>via</I> Inhibition of Reactive Oxygen Species and <I>UTH1</I> Gene Expression
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概要
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This study used a replicative lifespan assay of K6001 yeast to screen anti-aging food factors in commercial flavonoids. Hesperidin derived from the <I>Citrus</I> genus extended the lifespan of yeast at doses of 5 and 10 μM as compared with the control group (<I>p</I><0.01, <I>p</I><0.01). Reactive oxygen species (ROS), real-time PCR (RT-PCR), and lifespan assays of <I>uth1</I> and <I>skn7</I> mutants with the K6001 background were used to study the anti-aging mechanisms in yeast. The results indicate that hesperidin significantly inhibits the ROS of yeast, and <I>UTH1</I> gene expression, and that <I>SKN7</I> gene are involved in hesperidin-mediated lifespan extension. Further, increases in the Sir2 homolog, SIRT1 activity, and <I>SOD</I> gene expression were confirmed at doses of 5 (<I>p</I><0.01) and 10 μM (<I>p</I><0.05). This suggests that <I>Sir2</I>, <I>UTH1</I> genes, and ROS inhibition after administration of hesperidin have important roles in the anti-aging effects of yeast. However, the aglycon hesperetin did not exhibit anti-aging effects in yeast.
- Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文
著者
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Sakagami Youji
Graduate School Of Bio-agricultural Sciences Nagoya University
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Ishihara Satoru
Department Of Materials Science And Engineering Graduate Scool Of Engineering Osaka University
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Qi Jianhua
College Of Pharmaceutical Sciences Zhejiang University
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Matsuura Akira
Department Of Biology Faculty Of Science Chiba University
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Sun Kaiyue
College Of Pharmaceutical Sciences Zhejiang University
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Xiang Lan
College Of Biosystems Engineering And Food Science Zhejiang University
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