Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes

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概要

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• The anti-aging effects of phloridzin on the yeast Saccharomyces cerevisiae were investigated by employing a replicative lifespan assay of the K6001 yeast strain. After administrating phloridzin at doses of 3, 10, and 30 μM, the lifespan of the yeast was significantly prolonged in comparison with the untreated group (p<0.01, p<0.001). To determine the mechanism of action, anti-oxidative experiments and ROS assay were performed. Phloridzin improved the viability of the yeast dose-dependently under oxidative stress by 7.5 mM H2O2, and a low dose of phloridzin inhibited ROS of the yeast. Further, SOD1, SOD2, and Sir2 gene expression was examined by reverse transcription-polymerase chain reaction (RT-PCR), and was found to be significantly increased. Finally, superoxide dismutase (SOD) and SIRT1 activity assays showed that phloridzin notably increased the activity of SOD and SIRT1. These results suggest that SOD and Sir2 have important roles in phloridzin-regulated lifespan extension of yeast, and potentially anti-aging effects for mammalian cells via SIRT1.

• 2011-05-23

著者

• Suzuki Yoshihiro

  Graduate School Of Bioagricultural Sciences Nagoya University

• Sakagami Y

  Nagoya Univ. Nagoya Jpn

• Sakagami Youji

  Graduate School Of Bio-agricultural Sciences Nagoya University

• Lu Jun

  Department Of Environmental Biochemistry Graduate School Of Medicine Chiba University

• Qi Jianhua

  Coll. Of Pharmaceutical Sciences Zhejiang Univ.

• Wang Yan

  College Of Pharmaceutical Sciences Zhejiang University

• Qi Jianhua

  College Of Pharmaceutical Sciences Zhejiang University

• XIANG Lan

  College of Biosystems Engineering and Food Science, Zhejiang University

• SUN Kaiyue

  College of Pharmaceutical Sciences, Zhejiang University

• LU Jun

  College of Pharmaceutical Sciences, Zhejiang University

• WENG Yufang

  College of Pharmaceutical Sciences, Zhejiang University

• TAOKA Akiko

  Graduate School of Bioagricultural Sciences, Nagoya University

• Lu Jun

  College Of Pharmaceutical Sciences Zhejiang University

• Sun Kaiyue

  College Of Pharmaceutical Sciences Zhejiang University

• Taoka Akiko

  Graduate School Of Bioagricultural Sciences Nagoya University

• Xiang Lan

  College Of Biosystems Engineering And Food Science Zhejiang University

• Weng Yufang

  College Of Pharmaceutical Sciences Zhejiang University

• Suzuki Yoshihiro

  Graduate School of Bioagricultural Sciences, Nagoya University

• Qi Jianhua

  College of Pharmaceutical Sciences, Zhejiang University

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