Involvement of Glyceraldehyde-3-phosphate Dehydrogenase in the X-Ray Resistance of HeLa Cells

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概要

• 論文の詳細を見る

• We investigated changes in the sub-cellular distribution of glycelaldehyde-3-phosphate dehydrogenase (GAPDH) after X-ray irradiation in HeLa cells. Twenty-four h after irradiation at 5 Gy, nuclear GAPDH levels increased 2.6-fold, whereas total GAPDH levels increased only 1.2-fold. Knockdown of GAPDH using specific small interfering RNA (siRNA) led to sensitization to X-ray-induced cell death. These results suggest that GAPDH plays a role in the radioresponse.

• 社団法人 日本農芸化学会の論文
• 2008-09-23

著者

• Lu Jun

  Department Of Chemistry University Of Science And Technology Of China

• Suzuki Nobuo

  千葉大学 教育

• Suzuki Toshikazu

  Department of Internal Medicine, Daido Hospital

• SUZUKI Nobuo

  Department of Surgery, Tsuruoka City General Hospital

• Suzuki Toshikazu

  Department Of Environmental Biochemistry Graduate School Of Medicine Chiba University

• Lu Jun

  Department Of Aquatic Biosciences Faculty Of Fisheries Tokyo University Of Fisheries

• Suzuki N

  Dep. Of Environmental Biochemistry Graduate School Of Medicine Chiba Univ.

• LU Sa

  Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University

• Lu Jun

  Department Of Environmental Biochemistry Graduate School Of Medicine Chiba University

• Lu Sa

  Department Of Environmental Biochemistry Graduate School Of Medicine Chiba University

• Suzuki Toshikazu

  Dep. Of Environmental Biochemistry Graduate School Of Medicine Chiba Univ.

• Suzuki Norio

  Department Of Environmental Biochemistry Graduate School Of Medicine Chiba University

• Suzuki Toshikazu

  Graduate School Of Medicine Chiba University

• Suzuki Toshikazu

  Department Of Biuchemistry And Cell Biology.nalional Institute Of Infectious Diseaser

• Sato Nobutoshi

  Kanazawa Univ. Ishikawa Jpn

• Suzuki Nobuo

  Department Of Applied Physics Tohoku University

• Suzuki Nobuo

  Department Of Applied Physics Faculty Of Engineering Tohoku University

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