Ameliorative Effect of Captopril and Valsartan on an Animal Model of Diabetic Cardiomyopathy(Pharmacology)
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概要
- 論文の詳細を見る
The objective of this study was to clarify the relationship between angiotensin II and the pathogenesis of diabetic cardiomyopathy by observing the effects of related drugs on diabetic cardiomyopathy in rats. Captopril and Valsartan, an automatic biochemical analyzer, and radioimmunoassay technology were used to an experimental rat model of diabetic cardiomyopathy to dynamically measure the levels of creatine kinase-MB, lactate dehydrogenase-1 in the serum, and angiotensin I and II in the plasma, and to observe changes in the myocardial ultrastructure. The content of angiotensin I and II was increased and the renin-angiotensin system was in a hyperfunctional state in experimental rats with myocardial damage. Angiotensin-converting enzyme inhibitors and angiotensin II receptor 1 antagonists improved the myocardial structure and cardiac function. It is concluded that hyperfunction of the renin-angiotensin system is involved in the pathogenesis of diabetic cardiomyopathy, with an increase in angiotensin being a key factor. Preventing the increase in angiotensin II or the action of angiotensin II on its receptor can prevent the occurrence and development of diabetic cardiomyopathy.
- 社団法人日本薬学会の論文
- 2008-11-01
著者
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Lu Jun
Department Of Chemistry University Of Science And Technology Of China
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Lu Jun
Department Of Pharmacology School Of Medicine Xi'an Jiaotong University
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Sun Lei
Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China
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Yu Xiao-Jiang
Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China
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Zang Wei-Jin
Department of Pharmacology, School of Life Science and Technology, Xi’an Jiaotong University, China
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Zhang Chun-hong
Department Of Pharmacology School Of Medicine Xi'an Jiaotong University:department Of Endocrine
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Yu Xiao-jiang
Department Of Pharmacology School Of Medicine Xi'an Jiaotong University
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Zang Wei-jin
Department Of Pharmacology School Of Medicine Xi'an Jiaotong University:key Laboratory Of Envir
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Lu Jun
Department Of Aquatic Biosciences Faculty Of Fisheries Tokyo University Of Fisheries
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Sun Lei
Department Of Chemistry Rutgers The State University Of New Jersey
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Sun Lei
Department Of Cardiology Northern People's Hospital Medical College Of Yangzhou University
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Yu Xiao-jiang
Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University
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Zang Wei-jin
Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University
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Sun Lei
Department Of Pharmacology School Of Life Science And Technology Xi'an Jiaotong University
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Liu Jian-kang
Institute Of Mitochondrial Biology & Medicine School Of Life Science And Technology Xi'an J
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Liu Jian-kang
Institute Of Mitochondrial Biology & Medicine School Of Life Science And Technology Xi'an Jiaotong University
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