Involvement of Glyceraldehyde-3-phosphate Dehydrogenase in the X-Ray Resistance of HeLa Cells
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概要
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We investigated changes in the sub-cellular distribution of glycelaldehyde-3-phosphate dehydrogenase (GAPDH) after X-ray irradiation in HeLa cells. Twenty-four h after irradiation at 5 Gy, nuclear GAPDH levels increased 2.6-fold, whereas total GAPDH levels increased only 1.2-fold. Knockdown of GAPDH using specific small interfering RNA (siRNA) led to sensitization to X-ray-induced cell death. These results suggest that GAPDH plays a role in the radioresponse.
- 社団法人 日本農芸化学会の論文
著者
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Lu Jun
Department Of Chemistry University Of Science And Technology Of China
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Suzuki Toshikazu
Department of Internal Medicine, Daido Hospital
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SUZUKI Nobuo
Department of Surgery, Tsuruoka City General Hospital
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LU Sa
Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University
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