Amino Acid Sequence of Sardine Calcitonin and Its Hypocalcemic Activity in Rats

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概要

• 論文の詳細を見る

• A novel calcitonin (CT) was isolated from the spotlined sardine, Sardinops melanostictus. The primary structure of sardine CT was determined as follows : H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Ala-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Ser-Tyr-Pro-Arg-Thr-Asn-Val-Gly-Ala-Gly-Thr-Pro-NH_2. This amino acid sequence was different from that of salmon CT in 4 amino acid residues at positions 8th, 21th, 27th and 29th. As judged by the international method of CT bioassay, hypocalcemic activity of sardine CT was calculated as 4156 IU/mg. When compared for durability of CTs, it was found that sardine CT was significantly more potent than that of salmon CT. This is the first report of CT from a marine species of teleost.

• 社団法人日本動物学会の論文
• 1994-10-15

著者

• Sasayama Yuichi

  Noto Marine Laboratory Faculty Of Science Kanazawa University

• Sasayama Yuichi

  Department Of Biology Faculty Of Science Toyama University

• Takei Yoshio

  Ocean Research Institute, The University of Tokyo

• SUZUKI Nobuo

  Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University

• Suzuki N

  Noto Marine Laboratory Institute Of Nature And Environmental Technology Kanazawa University

• SAKAKIBARA SHUMPEI

  Peptide Institute Inc., Protein Research Foundation

• SUZUKI Nobuo

  Department of Surgery, Tsuruoka City General Hospital

• NAKAJIMA Kiichiro

  Peptide Institute Inc., Protein Research Foundation

• Nose Yasuhiro

  Department of Biology, Faculty of Science, Toyama University

• Kase Yoichi

  Department of Biology, Faculty of Science, Toyama University

• Nagasawa Hiromichi

  Ocean Research Institute, Tokyo University

• Watanabe X.

  Peptide Institute Incorporated, Protein Research Foundation

• Suzuki N

  Noto Marine Laboratory Faculty Of Science Kanazawa University

• Nakajima Keisuke

  Department Of Biology School Of Education Waseda University

• Takei Y

  Ocean Research Institute University Of Tokyo

• Takei Yoshio

  Division Of Marine Bioscience Ocean Research Institute The University Of Tokyo

• Takei Yoshio

  Ocean Research Institute University Of Tokyo

• Takei Yoshio

  Ocean Research Institute The University Of Tokyo

• Takei Yoshio

  Department Of Physiology Ocean Research Institute The University Of Tokyo

• Kase Yoichi

  Department Of Biology Faculty Of Science Toyama University

• Nose Yasuhiro

  Mukaishima Marine Biological Laboratory Faculty Of Science And Laboratory Of Marine Molecular Biolog

• Takei Yoshio

  Laboratory Of Physiology Department Of Marine Bioscience Ocean Research Institute The University Of

• Sakakibara Shumpei

  Peptide Institute Inc. Protein Research Foundation

• Sakakibara S

  Peptide Institute Incorporated Protein Research Foundation

• Watanabe X.

  Peptide Institute Incorporated Protein Research Foundation

• Nakajima Kiichiro

  Peptide Institute Inc. Protein Research Foundation

• Suzuki Nobuo

  Department Of Applied Physics Tohoku University

• Nagasawa Hiromichi

  Ocean Research Institute The University Of Tokyo

• Suzuki Nobuo

  Department Of Applied Physics Faculty Of Engineering Tohoku University

• Sakakibara Shumpei

  Peptide Center, Institute for Protein Research, Osaka University

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