Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.(Organic Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Three new acylated spermidines and two known related compounds were isolated from the Okinawan soft coral, Sinularia sp. These compounds were N', N", N"-trimethylspermidines that are acylated by a methylbranched unsaturated fatty acid. These acylspermidines showed potent cytotoxicity against human tumor cell lines at an IC_<50> value of 17 ng/ml and the induction of apoptotic phenomena.
- 社団法人日本農芸化学会の論文
- 2003-06-23
著者
-
張 雁
広島大学大学院 医歯薬学総合研究科 創生医科学専攻 先進医療開発科学講座 分子口腔医学・顎顔面外科学
-
Zhang Yang
Graduate School Of Engineering Hachinohe Institute Of Technology
-
Suzuki Yoshihiro
Graduate School Of Bioagricultural Sciences Nagoya University
-
Sakagami Y
Nagoya Univ. Nagoya Jpn
-
Sakagami Youji
Graduate School Of Bioagricultural Sciences Nagoya Univ.
-
Sakagami Youji
Graduate School Of Bio-agricultural Sciences Nagoya University
-
Okada Masahiro
Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.
-
OJIKA Makoto
Graduate School of Bioagricultural Sciences, Nagoya University
-
Islam Mohammad
Graduate School Of Natural Sci. And Technol. Okayama Univ.
-
Okamoto Tetsuji
Graduate School Of Biomedical Sciences Hiroshima Univ.
-
Ojika M
Graduate School Of Bioagricultural Sciences Nagoya University
-
Makoto Ojika
Graduate School Of Bioagricultural Sciences Nagoya University
-
SHINTANI Tomoaki
Graduate School of Biomedical Sciences, Hiroshima University
-
Okamoto T
Graduate School Of Biomedical Sciences Hiroshima University
-
Shintani Tomoaki
Graduate School Of Biomedical Sciences Hiroshima Univ.
-
Okamoto T
Graduate School Of Biomedical Sciences Hiroshima Univ.
-
Ojika Makoto
Graduate School Of Bioagricultural Sciences Nagoya Univ.
-
Islam Mohammad
Graduate School Of Biomedical Sciences Hiroshima University
-
Suzuki Yoshihiro
Graduate School of Bioagricultural Sciences, Nagoya University
関連論文
- 軟サンゴ由来抗腫瘍活性物質の精製とその作用機構
- エナメル上皮癌における新規可溶化性FGFR3受容体の同定
- 口腔扁平上皮癌細胞における MHC class 1 chain-related molecule A(MICA) および分泌型MICAの発現と TGF-beta による制御
- Developmental Signaling Disorders in Craniofacial Anomalies and Cancers
- 口腔粘膜上皮細胞および口腔扁平上皮癌細胞株における Patched-1 Splicing Variant の同定とその機能解析
- 正常ヒト唾液腺におけるアンジオポイエチン2とその受容体Tie2の機能解析
- ラット唾液腺由来幹細胞の増殖・分化におけるアクチビンAの作用
- Epidermal Growth Factor Receptor を標的とした扁平上皮癌の分子標的治療に関する研究
- 血管新生における Endothelial-specific Receptor Tyrosine Kinase Tie-2 遺伝子の機能
- 口腔扁平上皮癌細胞のマトリックスメタロプロプロテアーゼ2(MMP-2)活性化機構における線維芽細胞の関与
- ヘパリン親和性FGF結合蛋白HBp17の扁平上皮癌細胞における機能解析
- 野生型KGF受容体遺伝子導入による唾液腺由来腺癌細胞のアポトーシス誘導
- 頭蓋骨早期癒合症および軟骨無形成症の遺伝子診断
- ヒト歯周靭帯由来上皮細胞の細胞内分泌学的研究
- Wild-type KGFR 遺伝子移入によるヒト唾液腺由来腺癌細胞の増殖制御
- ヘパリン結合性FGF結合蛋白HBp17の正常および腫瘍細胞における発現とその機能解析
- Stereoselective Incorporation of Isoleucine into Cypridina Luciferin in Cypridina hilgendorfii (Vargula hilgendorfii)
- Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
- Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
- P-146 NOVEL POSTTRANSLATIONAL MODIFICATION : GERANYL MODIFICATION ON TRYPTOPHAN RESIDUE RESULTING FORMATION OF TRICYCLIC RING STRUCTURE
- Towards Structural Determination of the ComX Pheromone : Synthetic Studies on Peptides Containing Geranyltryptophan
- Short-Range Structure of Vitreous P_2O_5 by MD Simulation
- Welfare Effects of Nuisance Zoning
- Proline and Glycinebetaine Confer Cadmium Tolerance on Tobacco Bright Yellow-2 Cells by Increasing Ascorbate-Glutathione Cycle Enzyme Activities
- Fredericamycin A Affects Mitochondrial Inheritance and Morphology in Saccharomyces cerevisiae
- Construction of a Bacterial Artificial Chromosome Library for a Myxobacterium of the Genus Cystobacter and Characterization of an Antibiotic Biosynthetic Gene Cluster
- Biotransformation of Cystothiazole A, a Myxobacterial Antibiotic, into Novel Derivatives by the Mother Producer, Cystobacter fuscus
- Biosynthetic Studies on a Myxobacterial Antibiotic, Cystothaiazole A: Biosynthetic Precursors of the Carbon Skeleton
- New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 2. Structure Analysis
- New Cyclic Depsipeptide Antibiotics, Clavariopsins A and B, Produced by an Aquatic Hyphomycetes, Clavariopsis aquatica : 1. Taxonomy, Fermentation, Isolation, and Biological Properties
- Cystothiazoles A and B, New Bithiazole-type Antibiotics from the Myxobacterium Cystobacter fuscus
- Structural Studies and Antifungal Activity of Unique Polyene Amides, Clathrynamide A and Three New Derivatives, from a Marine Sponge, Psammoclemma Sp.(Organic Chemistry)
- Evaluation of Sliding Mode Idle-speed Control for SI Engines
- Proline and Glycinebetaine Ameliorated NaCl Stress via Scavenging of Hydrogen Peroxide and Methylglyoxal but Not Superoxide or Nitric Oxide in Tobacco Cultured Cells
- Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative
- アクチビンAによる唾液腺導管由来RSMG-1上皮細胞における腺房細胞マーカーSel-11遺伝子の発現誘導
- Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
- A Rapid and Efficient System of Agrobacterium Infection-Mediated Transient Gene Expression in Rice Oc Cells and Its Application for Analysis of the Expression and Antisense Suppression of Preprophytosulfokine, a Precursor of Phytosulfokine-α, Encoded by O
- Preparation and Characterization of Fully Active Biotinylated Analogs of Phytosulfokine-α
- Determination of the Luciferin Contents in Luminous and Non-Luminous Beetles
- Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium : Taxonomy, Production, and Biological Properties
- Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.(Organic Chemistry)
- Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
- P-494 Polymer-Assisted Solution-phase Synthesis of 15-Deoxy-Δ^-PGJ_2 Derivatives and their Neurite Outgrowth-Promoting Activity
- Prostaglandins from a Zoanthid : Paclitaxel-Like Neurite-Degenerating and Microtubule-Stabilizating Activities
- 16(I-2) Novel Saponins from the Okinawan Starfish Linckia laevigata : Structure Determination, Neuritogenic Activity, and Mechanism of Action
- A Functional Analysis of the Yeast Ubiquitin Ligase Rsp5: The Involvement of the Ubiquitin-Conjugating Enzyme Ubc4 and Poly-Ubiquitination in Ethanol-Induced Down-Regulation of Targeted Proteins
- Zooxanthellactone, a Novel γ-Lactone-type Oxylipine from Dinoflagellates of Symbiodinium sp : Structure, Distribution, and Biological Activity
- New Haliangicin Isomers, Potent Antifungal Metabolites Produced by a Marine Myxobacterium
- Cytosolic Alkalization and Cytosolic Calcium Oscillation in Arabidopsis Guard Cells Response to ABA and MeJA
- Roles of AtTPC1, Vacuolar Two Pore Channel 1, in Arabidopsis Stomatal Closure
- Linckosides M-Q : neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
- P-207 Linckosides, novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata
- P-145 CHARACTERIZATION OF A PHYTOPHTHORA MATING HORMONE
- Biosynthesis of 2'-O-Methylmyxalamide D in the Myxobacterium Cystobacter fuscus : a Polyketide Synthase-Nonribosomal Peptide Synthetase System for the Myxalamide D Skeleton and a Methyltransferase for the Final O-Methylation
- Novel Relationship between the Antifungal Activity and Cytotoxicity of Marine-Derived Metabolite Xestoquinone and Its Family
- Differentiation in a Rat PC12 Cell Line Induced by Ostruthin and (-)-Bornyl Ferulate, Constitutents of a Chinese Herbal Medicine
- Stomatal Density is Controlled by a Mesophyll-Derived Signaling Molecule
- Myrosinases, TGG1 and TGG2, Redundantly Function in ABA and MeJA Signaling in Arabidopsis Guard Cells
- Biosynthesis of Phytosulfokine, Plant Cell Growth Factor
- Phytosulfokine-α, a Peptide Growth Factor Found in Higher Plants:Its Structure, Functions, Precursor and Receptors
- BS-12-23 Defending Ad Hoc Network from Black Hole Attack(BS-12. Network Planning, Control, and Management)
- Highly Stereoselective Synthesis of (E)-Substituted Allylsilanes via the Still-Wittig Rearrangement
- Enzymatic and Genetic Characterization of Firefly Luciferase and Drosophila CG6178 as a Fatty Acyl-CoA Synthetase
- A Functional Analysis of the Yeast Ubiquitin Ligase Rsp5 : The Involvement of the Ubiquitin-Conjugating Enzyme Ubc4 and Poly-Ubiquitination in Ethanol-Induced Down-Regulation of Targeted Proteins
- Zooxanthellamide B, a Novel Large Polyhydroxy Metabolite from a Marine Dinoflagellate of Symbiodinium sp
- Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
- Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
- Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
- Proline and Glycinebetaine Ameliorated NaCl Stress via Scavenging of Hydrogen Peroxide and Methylglyoxal but Not Superoxide or Nitric Oxide in Tobacco Cultured Cells
- Proline and Glycinebetaine Confer Cadmium Tolerance on Tobacco Bright Yellow-2 Cells by Increasing Ascorbate-Glutathione Cycle Enzyme Activities
- Simple and Highly Efficient Transformation Method for Zymomonas mobilis : Electroporation
- Phytosulfokine Stimulates Somatic Embryogenesis in Cryptomeria japonica
- Anti-Aging Effects of Phloridzin, an Apple Polyphenol, on Yeast via the SOD and Sir2 Genes
- Recognition System for Dietary Fatty Acids in the Rat Small Intestine
- The Recognition System of Dietary Fatty Acids by the Rat Small Intestinal Cells
- Determination of the Luciferin Contents in Luminous and Non-Luminous Beetles
- Aplysiallene, a New Bromoallene as an Na, K-ATPase Inhibitor from the Sea Hare, Aplysia kurodai
- Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum
- New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
- New Neuritogenic Steroidal Saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl
- Visualization of the Articulation of Replaced Knee Joint Surfaces After Total Knee Arthroplasty
- Sensitivity Variation for H, B, Si, Cl, Ca and Cd in Solid Materials by Prompt Gamma-ray Analysis with a Special Emphasis on the Presence of Hydrogen
- Analogs of the CLV3 Peptide : Synthesis and Structure-Activity Relationships Focused on Proline Residues
- Novel Cytotoxic Polyoxygenated Steroids from an Okinawan Sponge Dysidea sp.
- Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus
- Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
- Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression
- Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus
- Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor
- Novel Cerebroside, Termitomycesphin I, from the Mushroom, Termitomyces titanicus
- Classification of Known and Unknown Environmental Sounds Based on Self-Organized Space Using a Recurrent Neural Network