Articulospora sp. Produces Art1, an Inhibitor of Bacterial Histidine Kinase
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概要
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A two-component system (TCS) comprising a histidine kinase (HK) sensor and a response regulator (RR) plays important roles in regulating the virulence of many pathogenic bacteria. We used a new screening method to isolate novel inhibitor Art1 against bacterial sensory HK from an acetone extract of solid cultures of Articulospora sp., an aquatic hypomycete. Art1 inhibited the ATP-dependent autophosphorylation of recombinant glutathione S-transferase-fusion protein SasA, a cyanobacterial HK, with an IC50 value of 9.5 μg/ml.
- 社団法人 日本農芸化学会の論文
著者
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Mizuno Takeshi
Graduate School Of Sci. & Engineering Saitama Univ.
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Sakagami Youji
Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Okada Masahiro
Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.
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FUDOU Ryosuke
Institute of Life Science, Ajinomoto Co., Inc.
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SUGAHARA Hirosuke
Graduate School of Bioagricultural Science, Nagoya University
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KONDO Tatsuhiko
Graduate School of Bioagricultural Science, Nagoya University
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IKEDA Yasuya
Graduate School of Bioagricultural Science, Nagoya University
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KAIDA Kenichi
Institute of Life Sciences, Ajinomoto Co., Inc.
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