Chemical Structure of Posttranslational Modification with A Farnesyl Group on Tryptophan
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概要
- 論文の詳細を見る
Bacillus subtilis and related bacilli produce a posttranslationally modified oligopeptide, the ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComXRO-C-2 pheromone from strain RO-C-2 must be modified with a farnesyl group on the Trp residue, but the precise structure is not known. Here we report the precise nature of posttranslational farnesylation of ComXRO-C-2 pheromone on the Trp residue, resulting in the formation of a tricyclic structure. The ComX168 pheromone, produced by the standard laboratory strain used in the study of B. subtilis, is also posttranslationally farnesylated according to phylogenetic resemblance.
- 社団法人 日本農芸化学会の論文
著者
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Dubnau David
Public Health Research Institute
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Sakagami Youji
Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Okada Masahiro
Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.
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Yamaguchi Hisao
Graduate School of Bioagricultural Sciences, Nagoya University
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Sato Isao
Graduate School of Bioagricultural Sciences, Nagoya University
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TSUJI Fumitada
Graduate School of Bioagricultural Sciences, Nagoya University
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Ojika M
Graduate School Of Bioagricultural Sciences Nagoya University
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Yamaguchi Hisao
Graduate School Of Bioagricultural Sciences Nagoya University
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