Acid Labile ComX Pheromone from Bacillus mojavensis RO-H-1
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概要
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Bacillus mojavensis strain RO-H-1 produces a posttranslationally modified hexapeptide, the ComXRO-H-1 pheromone, that stimulates natural genetic competence controlled by quorum sensing. LC/ESI-MS analysis of partially purification of the ComXRO-H-1 pheromone suggested a precise modification in its tryptophan residue. The corresponding ComXRO-H-1 pheromone prepared by solid-phase synthesis was identical to the natural pheromone, and showed significant biological activity. These results indicated that the posttranslational modification of the ComXRO-H-1 pheromone was geranylation on the tryptophan residue, resulting in the formation of a tricyclic structure. The ComXRO-H-1 pheromone was immediately dehydrated by acid because of its extreme acid lability.
- 社団法人 日本農芸化学会の論文
著者
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Dubnau David
Public Health Research Institute
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Sakagami Youji
Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Okada Masahiro
Graduate School Of Biological Sciences Nara Inst. Of Sci. And Technol.
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Yamaguchi Hisao
Graduate School of Bioagricultural Sciences, Nagoya University
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Sato Isao
Graduate School of Bioagricultural Sciences, Nagoya University
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TSUJI Fumitada
Graduate School of Bioagricultural Sciences, Nagoya University
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QI Jianhua
Graduate School of Bioagricultural Sciences, Nagoya University
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