ALLOPURINOL TOXICITY : ITS TOXIC ORGAN-SPECIFICITY BETWEEN THE LIVER AND THE KIDNEY IN THE RAT
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概要
- 論文の詳細を見る
In this study, allopurinol toxicity was investigated in the liver and the kidney in the rat. Allopurinol was intraperitoneally administered to rats, once a day, for 1, 3 or 10 days, in doses of 3, 10, 30 and 100 mg/kg body weight/day. At the 24th hour after the last administration, the rat was sacrificed, and blood and tissue samples were taken for analyses. In doses of 30 mg/kg/day and more, decreases of the body weight and the liver weight were observed, while the kidney weight increased. The plasma activities of alkaline phosphatase, glutamic oxaloacetic and glutamic pyruvic transaminases showed no increases, while the blood urea nitrogen and creatinine increased. These changes were the most remarkable in the 3 day administration, whereas they approached the control level thereafter. In doses of 10 mg/kg/day and less, no significant changes were observed in comparison to the control. These results denote that the minimal toxic dose ranges between 10 and 30 mg/kg/day, and that the kidney is more sensitive than the liver. In addition, these results also denote that the renal and hepatic failures are reversively restored even when allopurinol is further administered later than the 3 day. This fact suggests not only that the capacity inactivating allopurinol in the body is increased, but also that the enzymatic induction in the allopurinol inactivation system is accelerated.
- 日本トキシコロジー学会の論文
- 1984-11-25
著者
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Suzuki Yoshihiro
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine
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Suzuki Y
Department Of Applied Physics Faculty Of Engineering Tohoku University
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SUDO Jun-ichi
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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Tanabe Tsuneyoshi
Dept. Of Toxicol. & Clin. Pharmacol. Fac. Of Pharmaceut. Sci. Higashi-nippon-gakuen Univ.
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Tanabe Tsuneyoshi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Tanabe Tsuneyoshi
Department Of Toxicology And Clinical Pharmacology Faculty Of Pharmaceutical Sciences Higashi-nippon
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Tanabe Tsuneyoshi
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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Suzuki Yoshishige
National Institute For Advanced Interdisciplinary Research
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Suzuki Yoshihiro
Dept. Of Toxicol. & Clin. Pharmacol. Fac. Of Pharmaceut. Sci. Higashi-nippon-gakuen Univ.
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Sudo J
Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmceutical Sciences Health Sciences
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Sudo Jun-ichi
Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science
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Tanabe Tsuneyoshi
Dept. Of Toxicology And Clinical Pharmacology Fac. Of Pharmaceutical Sciences Higashi-nippon-gakuen
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Suzuki Yoshihiro
Department Of Civil And Environmental Engineering Faculty Of Engineering University Of Miyazaki
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Suzuki Yshiro
Department Of Applied Physics Faculty Of Engineering Tohoku University
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Suzuki Yoshio
Department Of Electronics Fukuoka Institute Of Technology
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Suzuki Yoshihiro
Department Of Biological Science Graduate School Of Sciences Kanagawa University
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Suzuki Yoshihiro
Department Of Advanced Materials Chemistry Faculty Of Engineering Yokohama National University
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