SEPARATION OF CEPHALORIDINE FROM THE RAT URINE CONTAMINATED BY FECES AND DIET PELLETS IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY : PRETREATMENT WITH STRONGLY BASIC ANION EXCHANGE RESIN FOLLOWING DEPROTEINIZATION
スポンサーリンク
概要
- 論文の詳細を見る
In this study, a high-performance liquid chromatographic method including a treatment with ion exchange resin following a deproteinization treatment, was studied for determination of cephaloridine in the rat urine which was contaminated by pieces of feces and diet pellets. The solvent system used Was 10% acetonitrile (v/v) in 0.1 M K_2 HPO_4 -H_3 PO_4 buffer, pH 7.5, and this was isocratically eluted on a reversed-phase column of NOVA-PAK C_<18>. The urine sample containing cephaloridine was deproteinized, treated with a strongly basic anion exchange resin of Dowex-1-Chloride, and then chromatographed. In comparison to the sample treated by the simple deproteinization, the residual substances after the deproteinization, which interfered the cephaloridine peak, were removed by the following treatment with Dowex-1-Chloride, as was confirmed using a three-dimensional computing spectrophotometric monitor. Thus, the present method is considered to be useful in determination of cephaloridine in such body fluids as urine in which many interfering substances are contained.
- 日本トキシコロジー学会の論文
- 1985-02-25
著者
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Ishihara Atsushi
Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine
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SUDO Jun-ichi
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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Ishihara Atsushi
Div. Of Applied Life Sciences Graduate School Of Agriculture Kyoto Univ.
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Ishihara A
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Ishihara Atsushi
Department Of Applied Chemistry Faculty Of Technology Tokyo University Of Agriculture And Technology
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Tanabe Tsuneyoshi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Tanabe Tsuneyoshi
Department Of Pharmacology And Toxitology Faculty Of Pharmaceutical Sciences
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Sudo Jun-ichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Sudo Jun-ichi
Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science
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Ishihara A
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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