CYCLIC AMP-DEPENDENT PROTEIN KINASE ACTIVITY AND ENDOGENOUS PROTEIN PHOSPHORYLATION IN ISOLATED CORTICAL SEGMENTS OF RABBIT NEPHRON
スポンサーリンク
概要
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Cyclic AMP-dependent protein kinase activity and endogenous protein phosphorylating activity are reported for 6 cortical segments of the rabbit nephron which were microdissected and collected according to their morphology. The 6 cortical nephron segments, namely the glomerulus (GIm), proximal convoluted tubule (PCT), proximal straight tubule (PST), cortical ascending limb of Henles loop (CAL), distal convoluted tubule (DCT), and cortical collecting tubule (CCT), showed protein kinase activities which were increased 1.8-4.9 fold by 10<SUP>-6</SUP> M cyclic AMP in the presence of histone IIA, histone f2b or histone f3 as a protein substrate. However, all these segments showed little or no cyclic AMP dependent increase of activity with either protamine or a-casein as a protein substrate. Cyclic AMP increased the endogenous protein phosphorylation of GIm (10<SUP>-6</SUP> M cyclic AMP), of CAL (10<SUP>-7</SUP> and 10<SUP>-8</SUP> M cyclic AMP), of DCT (10<SUP>-6</SUP> M cyclic AMP) and of CCT (10<SUP>-8</SUP>, 10<SUP>-7</SUP> and 10<SUP>-6</SUP> M cyclic AMP). In contrast, PCT showed decreased endogenous protein phosphorylation in the presence of 10<SUP>-7</SUP>, 10<SUP>-5</SUP> and 10<SUP>-4</SUP> M cyclic AMP.
- 社団法人 日本薬理学会の論文
著者
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Kimura Koji
Department of Cardiovascular Surgery, Medicine, Radiology, and Pathology, National Cardiovascular Ce
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Kimura Koji
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
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KOSEKI Chizuko
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Sudo Jun-ichi
Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science
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Koseki Chizuko
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
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Sakai Fuminori
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
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Yazawa Tomoko
Department Of Anesthesia Otsu Red-cross Hospital
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Kimura Koji
Department Of Animal Breeding And Reproduction National Institute Of Livestock And Grassland Science
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KIMURA Koji
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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YAZAWA Tomoko
Department of Internal Medicine, Tokyo Women's Medical College
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